Project Grant R16GM159631
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This $408,179 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The University of Texas Health Science Center at San Antonio (UTHSCSA). The award supports a research program to use state-of-the-art mass spectrometry-based proteomics tools to globally monitor and quantify changes in protein abundance, interactions, and post-translational modifications within the context of the...
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- This federal Project Grant award of $617,007 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of DNA double-strand break repair through non-homologous end joining (NHEJ). The research aims to elucidate how DNA ends are held together and coordinated with end processing enzymes to maximize the fidelity of NHEJ and minimize genome alterations. The...
- This Project Grant award, totaling $125,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research at Emory University to investigate the role of protein N-myristoylation in driving the DNA damage response (DDR), which is crucial for maintaining genomic stability. The research aims to: 1) assess the association of N-myristoylation, modulated by the enzymes NMT1 and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $854,927 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in Missouri. The grant, effective September 5, 2025 through August 31, 2027, will support research to define the mechanisms of a new pathway for genome stability, known as RNA Damage Induced DNA Breaks (RDIBS). The key objectives are to identify the types of RNA modifications that activate RDIBS, the...
- This $357,666 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support a 5-year research project conducted by the University of Missouri System to study the coordination of complex dynamics by DNA manipulating enzymes. Specifically, the project will use a combination of single molecule methods, including magnetic tweezers-based force and torque measurements and single molecule...
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
This Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences (NIGMS), supports research on the mechanisms of protein sumoylation and its role in DNA repair. The $148,228 award to Texas State University will be used to determine how DNA binding, ATP hydrolysis, and sumo interactions of the subunits of the SMC5/6 complex contribute to the efficient sumoylation of key proteins involved in homologous recombination and DNA double-strand break repair. The project aims to provide a better understanding of how the SMC5/6 complex, a critical regulator of genome maintenance, collaborates with its SUMO E3 ligase subunit to control protein sumoylation at DNA damage sites. This work is expected to yield insights into the mechanisms of DNA repair that are relevant to understanding and potentially preventing genomic instability and cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $148.2k | 8/6/25 |