Project Grant R01GM161048
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- The University of Chicago was awarded a $391,951 Project Grant under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025 through August 31, 2030. The grant supports fundamental scientific research at the interface of chemistry and biology to understand the role of lysyl oxidase (LOX) enzymes and related protein post-translational modifications in cancer signaling, immune regulation, and disease...
- The University of Massachusetts was awarded a $398,869 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This grant, effective from July 1, 2025 to April 30, 2030, supports research to directly characterize the load-sensitive steps in the mechanochemical cycle of myosin, a key molecular motor involved in cellular processes like muscle contraction and vesicular transport. The project aims to...
- The National Institute of General Medical Sciences (NIGMS) awarded a $534,450 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant, effective July 1, 2025 through June 30, 2030, supports the university's "Dual-Mentored Training for Collaborative Molecular Biophysics" program. This program trains graduate students in an interdisciplinary curriculum combining the physical and life sciences, with each student...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $410,000 in funding to the University of Chicago to conduct research on bacterial secretion systems using cryo-electron tomography. The key objectives are to: Investigate the assembly, disassembly, and function of bacterial flagellar motors (type III secretion systems) and type IV secretion systems, which are involved in...
- The University of Chicago received a four-year $900,000 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) to conduct computational studies of P-type ATPase ion pumps. The university will use theory, molecular dynamics simulations, and computational methods to elucidate the fundamental principles governing the function of sodium-potassium and calcium pumps at the atomic level. The research aims to address major biological questions about these...
- The University of Chicago was awarded a $625,000 Project Grant from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences CFDA program. This three-year collaborative research project will elucidate the molecular mechanisms underlying the activation of ROBO receptor proteins that guide the growth and navigation of axons during neural circuit development. The research aims to determine how ROBO receptors have evolved to allow for the...
- This federal Project Grant award of $150,104.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a computational framework for investigating the dynamics of actin filament branch formation and aging. The research will focus on understanding the role of nucleotide state and ATP hydrolysis in the actin-related protein (Arp) 2 and Arp3 subunits of the Arp2/3 complex during branch formation,...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal Project Grant award provides $501,879.00 to the University of Chicago to conduct collaborative research on the structural and functional mechanisms of a molecular conveyor belt machinery that drives bacterial gliding motility. The project aims to determine how multiple rotary motors on the bacterial surface coordinate to propel a protein-based conveyor belt, enabling cell movement analogous to a molecular...
The University of Chicago was awarded a $1,906,969.00 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) by the National Institutes of Health to conduct research on the molecular basis for myosin-10 regulation. The proposed study aims to investigate how ligand binding, myosin quaternary structure, and actin filament architecture influence the motility of myosin-10, a motor protein critical for cellular processes like intracellular trafficking, cell division, and cell motility. The research will integrate structural biology techniques and a systematic investigation of the ligands that activate and regulate myosin-10 processive motility. This work is expected to yield a molecular mechanism for cytoskeletal motor regulation, with potential implications for understanding and addressing diseases related to cell migration and motility. The project period runs from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/28/25 |