The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, awarded a $508,315 Project Grant to the University of California, San Diego (UCSD) to support research on gene regulatory mechanisms driving development during the period of transcriptional silence from oocyte to embryo in mammals. The 5-year project, starting on January 1, 2025, aims to uncover the molecular mechanisms required for successful...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $611,728 to the University of California, Berkeley to conduct research on the molecular mechanisms by which the transcription factor Dorsal controls gene expression dynamics during early embryonic development in Drosophila melanogaster. The key objectives are to: (1) determine how Dorsal modulates transcriptional...
This Project Grant award, valued at $775,170, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The funding supports research by the University of California, San Diego (UCSD) to investigate the organization and function of regulatory DNA, which controls gene expression patterns during development and in response to stimuli. Using experimental and computational approaches, the research aims to...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,553,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of California, Berkeley (UC Berkeley) effective September 1, 2024. The grant will fund research to identify calcium ion (Ca2+) channels and transporters that control dynamic changes in cytosolic Ca2+ levels, and uncover regulatory mechanisms for how these Ca2+-transporting proteins are regulated by external cues. The research...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $406,250.00 in funding to The Trustees of the University of Pennsylvania, with a period of performance from June 1, 2025 to April 30, 2030. The award supports research focused on two main directions: 1) understanding how transcription factor families coordinate complex developmental pathways to generate diverse...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $986,486 Project Grant to the University of California, Berkeley. The goal of this 5-year project, starting on May 6, 2025, is to develop new synthetic disconnections, strategies, and concepts to rapidly produce biologically important and complex molecules. This includes natural products from the Euphorbiaceae and Thymelaeaceae plant families, which...
The University of California Irvine will use a $2.83 million project grant from the Department of Health and Human Services' National Institute of General Medical Sciences to decipher the mechanism of long-range gene regulation in vivo. Over a three-year period ending August 2025, UC Irvine researchers will utilize efficient enhancer replacement technology in mice to systematically characterize long-range enhancer activity and identify cis-regulatory sequences critical to this function. A...
This federal Project Grant award of $651,596 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research by the Cold Spring Harbor Laboratory (CSHL) to study the molecular mechanisms that coordinate gene expression, cell fate determination, and tissue growth during development. The key research objectives are to: 1) Determine the molecular structures and dynamics of three transcriptional complexes that regulate...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, is funding research to gain insights into how biological timers control development and how the apical extracellular matrix (AECM) is constructed and remodeled in nematodes. The $381,801 award, effective August 1, 2025 through May 31, 2030, will support three interconnected projects: 1) determining how biological timers...
The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $787,500 Project Grant under CFDA 93.859 Biomedical Research and Research Training to the Regents of the University of California at Riverside. This grant will support research to investigate the roles of nuclear RNA modifications in gene regulation. The project aims to study three key nuclear RNA modifications - the 5' polyphosphate group, the m2,2,7G cap, and the m5C modification - and how they impact mRNA,...