Project Grant R35GM158192
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This Project Grant award of $562,320 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Oakland University to determine the role of pseudouridine synthases in regulating autophagy, a critical cellular process for maintaining health and survival under stress conditions. The research aims to elucidate the molecular mechanisms underlying cellular responses necessary for survival, which is a...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the phase behavior of proteins in crowded cellular environments. The $441,108 award, spanning from Sep 2024 to Aug 2027, will enable researchers at Louisiana State University to: 1) Study the effects of molecular crowding on the phase transition of model protein/polymer systems; 2)...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $407,562 to the University of Denver to conduct research on the molecular mechanisms of lysosome remodeling in response to cellular stress. The 5-year project, starting September 1, 2025, aims to characterize the degradation pathways of vacuole membrane proteins and investigate the transcriptional regulation of...
- This $414,159 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the differential stress responses of organelles in eukaryotic cells. The research aims to investigate the molecular mechanisms underlying how cells employ different strategies to respond to nutritional deprivation versus endoplasmic reticulum (ER) stress. The principal investigator at the...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $1,565,823.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to understand the biological mechanisms underlying the autophagy-lysosome system and its role in cellular quality control and aging processes. The principal investigator at Louisiana State University (LSU) aims to investigate how the dynamic transformation of lysosomes into expanded tubular networks can enhance...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research on the mechanisms of mitophagy, a form of mitochondrial quality control, and its role in promoting tissue health and homeostasis. The $373,129 award to Wayne State University will be used to generate genetic tools to manipulate different forms of mitophagy in the fruit fly model organism Drosophila melanogaster. The research...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $375,000 to Louisiana State University Health Sciences Center New Orleans to investigate the roles of the protein MASK as a regulator of autophagy, a cellular process that is critical for cell survival under various stresses. The research aims to 1) decipher the molecular mechanisms by which MASK promotes autophagy independently of the mTOR pathway, and 2) unravel MASK's influence on RNA splicing, metabolism, and translation. The award period runs from August 5, 2025 to July 31, 2030. This research has the potential to advance the understanding of fundamental biological processes and inform the development of new approaches for addressing neurodegenerative and other diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $375.0k | 8/4/25 |