The National Institute of General Medical Sciences (NIGMS) awarded a $306,873 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Osem Fluidics Inc. in Alhambra, CA. The goal of this 1.5-year project is to develop 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. The research aims to overcome limitations of current LNP manufacturing methods by providing an additional process parameter - channel architecture - to rapidly tune LNP properties in a customizable manner. The project will focus on designing, simulating, and testing 3D channel architectures to manipulate flow conditions and LNP properties, structurally characterize the LNPs, and demonstrate robust encapsulation of mRNA, siRNA, and pDNA for therapeutic applications.
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