This federal Project Grant award, totaling $427,571, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The funding supports research to uncover the molecular determinants of cellular identity and how chromatin states regulate the cell cycle. The project aims to develop new time-resolved structural epigenomic approaches to track the temporal dynamics of heterochromatin during replication and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $515,504.00 to St. Jude Children's Research Hospital Inc. to conduct research on dissecting the contributions of phase separation to yeast transcription. The research aims to investigate how transcription factors, coactivators, and DNA phase separate together, and how multivalent interactions and solubility...
The Project Grant award R35GM149520 in the amount of $775,170 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to decode the regulatory mechanisms within the human genome. The project aims to better understand how transcription factors and other regulatory DNA features cooperatively control gene expression patterns during development and in response to various stimuli. Using advanced...
The federal Project Grant award R35GM152063, funded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859), supports research on the epigenetic regulation of transcriptional programming. The $1,360,400 award, effective from July 5, 2024 to May 31, 2029, will be performed by Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated, to investigate the dynamic competition between Polycomb...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $462,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. to support the discovery of chemical modulators of RNA-protein assemblies through the systematic targeting of DEAD-box RNA-dependent ATPases. This 5-year research project aims to identify allosteric compounds that act as "glues" to stabilize DEAD-box proteins in complex with RNA, optimize...
The National Cancer Institute (NCI) awarded a $148,568 Project Grant under the Cancer Research Manpower Program (CFDA 93.398) to St. Jude Children's Research Hospital in Memphis, Tennessee. The goal of this 3-year project, with a start date of December 25, 2024 and end date of July 14, 2027, is to elucidate the mechanism by which a gene essential for rhabdoid tumor cell viability regulates chromatin function. The project will leverage CRISPR-Cas9 screening and molecular/genomic approaches to...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $568,113 to support research into variant chromatin structures and their functions in eukaryotic cells. The award recipient, The Research Foundation For The State University Of New York (doing business as Stony Brook University), will investigate the targeting and roles of two specific chromatin variants - the...
This $818,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program supports a research project at The Johns Hopkins University. The project aims to investigate how chromatin plasticity and nuclear RNA influence DNA repair mechanisms across different cell states and physiological contexts. Specifically, the project has two complementary components: 1) Examining how the DNA repair functions of the...
This federal Project Grant award, with ID R35GM154927, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The $411,250 award, commencing on July 15, 2024, supports research to investigate how changes in intracellular and extracellular metabolites, particularly polyamines, affect chromatin biology and cell fate. The research, led by the Trustees of Columbia University in the City of New York, Health...
This $1,449,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to study the fundamental regulation of extrachromosomal DNA (ecDNA) in cancer genomes. The project aims to develop new live-cell chromatin labeling strategies and integrate advanced imaging, synthetic genome engineering, and optical/genetic perturbation to systematically investigate how ecDNA orchestrates massive...