The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $667,480 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. on May 1, 2025. The grant supports a 5-year research project focused on studying the structural and functional dynamics of chromatin, which plays a critical role in cellular processes like gene expression, DNA replication, and cell differentiation. The research aims to advance the understanding...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to investigate the effects of polyamines on chromatin function and their impact on cell fate and chromatin homeostasis. The 5-year, $411,250 award to The Trustees of Columbia University in the City of New York will enable the principal investigator to explore how changes in intracellular and extracellular polyamines...
The National Institute of General Medical Sciences (NIGMS) awarded a $401,914 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation For The State University Of New York (RF SUNY) for a 5-year research project beginning February 1, 2025. The project aims to elucidate the evolutionary, biomedical, and functional impact of genomic structural variations, including deletions, duplications, inversions, and translocations of large DNA...
This $2,970,082 Project Grant from the Department of Health and Human Services' Assistant Secretary for Financial Resources, under the National Institute of General Medical Sciences' Biomedical Research and Research Training program (CFDA 93.859), will support research into the cross-regulation between loop extrusion, chromatin fiber structure, and chromatin-associated RNAs in mammalian genomes. The awardee, Rockefeller University, will conduct experiments from September 2022 to August 2025 to...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $156,980 to The Johns Hopkins University to conduct research on the mechanisms of SAGA (SPT-ADA-GCN5-ACETYLTRANSFERASE) complex regulation by histone crosstalk. The research aims to study the acetylation activity of the SAGA complex on mono- and di-nucleosomes with biologically relevant post-translational modifications, as...
This federal Project Grant award for $275,581, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports a research program at Colorado State University (CSU) to study the mechanisms and functions of three-dimensional chromatin structures in quiescent cells. The key objectives of this five-year research project are to: 1) uncover how the chromatin structural complex condensin relocates and forms loop...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $144,362.00 to The Research Foundation For The State University Of New York to investigate the mechanism of Ess1-mediated regulation of the CTD of RNAP II phase separation. The project will be conducted at the Upstate Medical Center in Syracuse, NY and is expected to be completed by April 30, 2025. This research aims to...
This Project Grant award of $442,750.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research at Virginia Polytechnic Institute & State University (Virginia Tech) focused on investigating the regulation of canonical and non-canonical substrates of histone lysine methyltransferases. The research aims to advance understanding of active chromatin inheritance and non-canonical methylation events...