This $528,129 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human diseases. The overarching goal is to develop a detailed understanding of how ubiquitin-proteasome pathway (UPP) components recognize substrates and execute their function, which is crucial for developing new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $410,000.00 to Princeton University to conduct research on the molecular determinants of biomolecular condensate assembly and spatial organization within heterogeneous intracellular environments. The 5-year project, running from September 1, 2024 to June 30, 2029, will leverage computational modeling and machine learning to...
The National Institute of General Medical Sciences (NIGMS) has awarded a $365,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Montclair State University. The grant will fund research to study the structural mechanism of spontaneous ubiquitin cargo clustering on the cell plasma membrane. The principal investigator will use fluorescence microscopy and atomic force microscopy techniques to identify the structural organization of ubiquitin cargo...
This Project Grant award of $125,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to uncover the molecular principles underlying the formation and functions of nuclear speckles, which are essential biomolecular condensates involved in regulating gene expression. The project aims to develop a comprehensive understanding of how the modular architecture of RNA-binding proteins,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $410,000.00 over 5 years to support research by The Trustees of Princeton University on the molecular structures and interactions that sustain biomolecular condensates, with a focus on stress granules. The research aims to develop accurate and efficient computational models to characterize the molecules within stress...
This federal Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $120,681 to Syracuse University to conduct collaborative research on how intrinsically disordered proteins provide protection against dehydration across different organisms. The research aims to gain a holistic understanding of how these disordered proteins and the cellular environment work together to protect cells during extreme desiccation. The project will employ a...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,542,717 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Delaware. The grant funding will support a research project titled "Deciphering Protein Ubiquitination with Chemical Biology Tools - Ubiquitination as a Reversible Post-Translational Modification is Essential to a Broad Range of Cellular Processes in Humans." The project aims to investigate the recognition and...
This $1,380,568 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports an interdisciplinary research project at the University of Chicago. The project aims to develop a comprehensive, multiscale understanding of how cells adapt to changes in their environment, which could lead to new therapeutic interventions for diseases related to maladaptive cellular states. The research is...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $396,250.00 to Vanderbilt University to conduct research on the regulation and function of biomolecular condensates. The research aims to define the core biochemical principles underlying the spatial and temporal regulation of P granule polarization during C. elegans embryogenesis, using P granules as a model condensate. Key...
The federal Project Grant award, with ID R35GM156454, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award, totaling $440,000.00 and granted on February 3, 2025, supports a research program focused on in-depth exploration of the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteome homeostasis or proteostasis. The key objectives of this project are to...