Project Grant R35GM158052

Award Date 6/1/25
Completion Date 5/31/30
Dollars Obligated $424K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Ann Arbor, MI 48109, USA
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The key products and services to be delivered under this 5-year grant include:

  • Development of bioinformatics methods to enable discovery of differentially expressed gene isoforms, allele bias, and isoform switching from bulk long-read RNA-seq data
  • Development of methods to identify new cell types based on unique gene isoform expression patterns in long-read single-cell RNA-seq data
  • Establishment of data collection and analysis guidelines for the advanced quantitative analysis of long-read RNA sequencing
  • Application of the developed methods to the awardee's own data as well as publicly available data to investigate gene isoforms in stem cells, neuroscience, and other biomedical contexts

This project builds upon the awardee's extensive expertise and prior contributions in the field of long-read sequencing bioinformatics, aiming to advance the quantitative analysis capabilities in this area to drive new biomedical discoveries.

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