The National Human Genome Research Institute (NHGRI), a component of the National Institutes of Health (NIH), awarded a $409,699 Project Grant under the Human Genome Research (CFDA 93.172) program to the Regents of the University of Michigan. The award, effective July 1, 2024 through April 30, 2027, supports the development of a combination of liquid chromatography-tandem mass spectrometry (LC-MS/MS) and nanopore sequencing methods to directly detect and quantify RNA chemical modifications in tRNA, rRNA, and mRNA.
The University of Oregon and Northeastern University received sub-awards to collaborate on this project. The University of Oregon will focus on developing nanopore direct RNA sequencing methods, RNA purification, and computational analysis. Northeastern University will contribute expertise in nanopore technology, molecular biology, and software development. This multi-institutional effort aims to enable comprehensive and quantitative detection of various RNA modifications, which is critical for advancing genome research and genomic medicine applications.
Generated 3/4/25, 8:09 AM