Project Grant R35GM157976
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
- The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to the University of California, Davis to investigate the role of the mismatch repair proteins MSH2 and MSH6 in maintaining genome stability. The 2-year project aims to delineate the mechanisms by which MSH2-MSH6 rejects mismatched recombination intermediates and determine the clinical significance of losing this activity in...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This Project Grant award of $524,815 was provided by the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) to Saint Louis University (SLU) on August 28, 2025. The grant supports research aimed at understanding the mechanisms of homologous recombination (HR), a DNA repair pathway critical for maintaining genomic stability. The key focus is on elucidating how mediator proteins and RAD51 paralogs facilitate the formation and stabilization of the RAD51 nucleoprotein...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research to study the mechanisms of how homologous recombination maintains genomic stability and induces genome rearrangements. The $305,927 award, effective September 1, 2025, will enable researchers at the University of California, Davis to advance their work on understanding the processing of displacement loops, a central recombination intermediate, as well as the roles of the double-stranded DNA motor proteins Rad54 and Rad54B in homologous recombination. This research aims to establish foundational paradigms using the budding yeast Saccharomyces cerevisiae as a model system, and then translate these insights to human cells and tumor genomics. The award supports the development of new experimental tools to detect recombination intermediates and products, which will help address critical gaps in the understanding of this important DNA repair mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $305.9k | 9/1/25 |