Project Grant K99GM155658
- This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research to study the mechanisms of how homologous recombination maintains genomic stability and induces genome rearrangements. The $305,927 award, effective September 1, 2025, will enable researchers at the University of California, Davis to advance their work on understanding the processing of...
- This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
- This Project Grant award of $254,919.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of California, San Diego (UCSD) to investigate the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Specifically, the research aims to study how post-translational modification enzymes regulate the assembly and function of DNA replication...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences (NIGMS), supports research on the mechanisms of protein sumoylation and its role in DNA repair. The $148,228 award to Texas State University will be used to determine how DNA binding, ATP hydrolysis, and sumo interactions of the subunits of the SMC5/6 complex contribute to the efficient sumoylation of key proteins involved in...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $225,852 Project Grant to The Leland Stanford Junior University to investigate the mechanisms that promote reliable formation of meiotic crossovers, which are essential for orderly chromosome segregation and genome inheritance. The research will focus on the COSA-2 protein, a critical component of the crossover machinery, and use innovative...
- This $900,000 federal Project Grant awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports a collaborative research project led by North Carolina State University to unravel the mechanisms behind the workings of the DNA mismatch repair systems. The research aims to elucidate the role of atypical nucleic acid structures, such as three-way junctions and R-loops, in driving the expansion of simple sequence repeats (SSRs) within the genome, which is a...
- The Research Foundation for the State University of New York (SUNY) received a $400,000 Project Grant from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under CFDA 47.074 - Biological Sciences. The project aims to improve understanding of the DNA mismatch repair (MMR) pathway and how changes in the behavior of mismatch repair proteins can lead to genome instability, particularly in the presence of specific DNA sequences like repetitive elements. Key project...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $125,000 Project Grant under CFDA 93.859 (Biomedical Research and Research Training) to the University of California, Davis to investigate the role of the mismatch repair proteins MSH2 and MSH6 in maintaining genome stability. The 2-year project aims to delineate the mechanisms by which MSH2-MSH6 rejects mismatched recombination intermediates and determine the clinical significance of losing this activity in MSH2/6-deficient patient tumors. Specifically, the research will use genetic and genomic approaches in the yeast model Saccharomyces cerevisiae to examine recombination between a double-strand break and perfectly matched versus mismatched templates, as well as transfer these proximity ligation assays to human cell lines. This fundamental research seeks to advance the understanding of how mismatch repair proteins preserve genome integrity and prevent cancer-associated genomic rearrangements.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 7/28/25 |