Project Grant R35GM154651

The University of New Mexico Health Sciences Center (UNM HSC) was awarded a $381,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the cellular mechanisms of lysosomal damage response. The grant, which runs from September 1, 2024 to August 31, 2029, will focus on two primary goals: (1) establishing the precise function of stress granule formation in controlling lysosomal quality, and (2) determining how lysosomal damage induces stress granule formation. The multidisciplinary research team will employ advanced techniques such as high-content microscopy, lysosome immunoprecipitation, proteomic analysis, and RNAi screening to reveal novel insights into how cells respond to lysosomal damage, the nature of stress granule formation, and inter-organelle interactions under stress conditions. The findings have the potential to facilitate innovative therapies for diseases associated with lysosomes and stress granules.