The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Nebraska Medical Center (UNMC) in the amount of $788,940.00 with a period of performance from July 15, 2024 to June 30, 2029. The funding will support research to investigate the function of bacterial cytoskeletal elements in the division and growth of the FtsZ-less Chlamydia bacteria. The project aims to 1) understand how the cytoskeletal protein MreB is maintained at the division septum and how daughter cell outgrowth occurs during the budding process, and 2) investigate a novel bactofilin cytoskeletal element that functions in maintaining cell size in Chlamydia. The research seeks to enhance the understanding of the evolutionary strategies used by Chlamydia to regulate critical physiological functions in the absence of the FtsZ protein, which is central to cell division in most bacteria. Findings from this work may identify Chlamydia-specific targets for antimicrobial development to limit the impact on the microbiome during treatment of Chlamydia infections.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 11/6/24 | ||
| Not listed | $394.5k | 7/11/24 | ||
| Not listed | $394.5k | 7/11/24 |