Project Grant R35GM151971

Award Date 7/15/24
Completion Date 6/30/29
Dollars Obligated $789K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Omaha, NE 68198, USA
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The funding will support research to investigate the function of bacterial cytoskeletal elements in the division and growth of the FtsZ-less Chlamydia bacteria. The project aims to 1) understand how the cytoskeletal protein MreB is maintained at the division septum and how daughter cell outgrowth occurs during the budding process, and 2) investigate a novel bactofilin cytoskeletal element that functions in maintaining cell size in Chlamydia. The research seeks to enhance the understanding of the evolutionary strategies used by Chlamydia to regulate critical physiological functions in the absence of the FtsZ protein, which is central to cell division in most bacteria. Findings from this work may identify Chlamydia-specific targets for antimicrobial development to limit the impact on the microbiome during treatment of Chlamydia infections.

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