The National Institute of General Medical Sciences (NIGMS) awarded a $403,750 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Duke University. The grant supports a research project titled "Structure, Function, and Evolution of Gene Regulatory Networks in Archaea" led by the Schmid Lab. The broad goal is to understand how stress response mechanisms evolved in archaea, which are the evolutionary progenitors of eukaryotes. The research will use...
This Project Grant award, valued at $133,246, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding will support the development of flexible Bayesian statistical methods to gain a comprehensive understanding of microbial community dynamics using high-throughput sequencing data. The key objectives are to create a general method for inferring microbial community dynamics that vary with...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $550,108 to the University of California, Merced to conduct research on the genetic regulation of microbial community formation, with a focus on biofilms. The project aims to investigate the molecular and mechanistic bases of biofilm development, including how transcriptional networks underlie gene expression during...
The National Institute of General Medical Sciences (NIGMS) awarded a $422,931 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Colorado-Denver on July 1, 2025. The goal of this 5-year research project is to characterize how specialized microbial metabolites mediate interactions within the human microbiome, and how these metabolite-driven community dynamics influence susceptibility to antimicrobial treatments. The research will integrate cheminformatics...
This $1,050,000 Project Grant, awarded by the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074), aims to study how extreme environments shape the regulatory networks of transcription in microbes called archaea. The research project, conducted by Duke University, will focus on haloarchaea - a group of archaea that thrive in extremely salty environments. The project's key objectives are to: (1) use genetics, genomics, and statistical modeling to compare the architecture...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This federal Project Grant award, identified as R35GM152049, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program. The $492,000 award supports a 5-year research project conducted by The Trustees of Princeton University that aims to expand the chemical space of microbial and microbiome natural products. Key objectives include elucidating cryptic metabolites in diverse microbial genera, especially...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $349,681 to the University of Maryland, College Park to develop two novel force nanoprobes for visualizing and quantifying intracellular forces in living cells. The first nanoprobe will convert applied mechanical stress into photons to directly measure intracellular forces. The second nanoprobe will use dynamic DNA...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) federal grant program, provides $395,701 to the University of Texas at Austin over a 5-year period from June 1, 2025 to May 31, 2030. The funding supports research to better understand the interactions between microbes and their animal hosts, with a focus on how microbial communities are shaped and how they affect the health of their hosts,...
This NSF Biological Sciences (CFDA 47.074) Project Grant award of $600,000 to Emory University will investigate how microbiome communities, which are communities of bacteria and other microbes that live in and on organisms, can resist change and transition to alternate states. The project will use the nematode worm Caenorhabditis elegans as a model host to better define the stability and properties of alternate microbiome states, as well as how factors like antibiotic treatment and host...