This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support the development of advanced statistical approaches for performing large-scale composite hypothesis testing in translational genetics research. The $408,750 award, granted to the University of Texas MD Anderson Cancer Center, aims to create novel, interpretable, and robust methods for conducting pleiotropy,...
This $385,700 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel computational approaches for pharmacogenomics research on complex diseases. The key objectives include: 1) Devising advanced deep learning models to predict molecular and phenotypic effects of genetic and chemical perturbations on disease models, 2) Leveraging large language models to...
This $752,456 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and application of innovative computational technologies for the design of small-molecule ligands. The key products and services to be delivered over the 5-year project period include: Creating a large database of predicted protein-ligand complexes to improve the accuracy of structure-based machine learning...
This $198,750 Project Grant awarded by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) supports the development of innovative computational models to leverage spatially resolved single-cell transcriptomics data. The goal is to create models that can identify tissue structures and pathological manifestations, and provide underlying spatial cellular and molecular signatures, particularly for new or uncharacterized diseases. The...
This $294,647 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of a theoretical, computational, and experimental framework to model epigenetic regulatory networks in single human cells. Key products and services include: The awardee, the University of Texas at Dallas (UTD), will rapidly assemble and stably integrate libraries of CRISPR-based epigenetic regulators in human...
This federal Project Grant award of $387,579 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to advance computational modeling of disease metabolism by integrating artificial intelligence (AI) and systems biology. The project seeks to address critical gaps in current metabolic analyses by developing a systematic and data-driven approach to characterize metabolic landscapes in disease systems, leveraging...
This $358,063 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of a comprehensive computational framework to track the effects of variable, time-dependent adaptation in biological systems. The 5-year project aims to: 1) design a mathematical framework for modeling dynamic adaptation, 2) validate computational models using experimental gene expression and sequencing...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $272,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco (UCSF) to develop AI4HEALTH, a game-based learning environment to engage diverse adolescents in exploring biomedical careers and applying artificial intelligence (AI) to solve health science problems. The project aims to promote interest in biomedical careers,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of computational models and machine learning approaches for the rational design of carbohydrate-based drugs and nucleic acid-based imaging agents. The total funding amount is $365,630, with the award period running from September 10, 2024 to July 31, 2029. The project aims to create large, high-quality datasets...
This Project Grant award of $1,005,000 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research aimed at defining and avoiding molecular mechanisms of drug resistance. The research combines experimental and computational techniques to elucidate the mechanisms of drug resistance, particularly in rapidly evolving viruses, and to develop strategies to preemptively avoid resistance in drug design. Key focus...