The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Massachusetts Medical School (UMass Medical) in the amount of $230,312. The award, with a project period from August 1, 2024 to July 31, 2029, will support research to investigate RNA interference and related gene regulatory mechanisms, particularly in the context of the C. elegans model organism. Key areas of...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $243,713 to the University of Massachusetts Medical School (UMass Medical) to conduct a comprehensive analysis of epistasis in drug resistance potential of the MPRO protease from SARS-CoV-2. The project aims to systematically investigate the interdependence of mutations that disrupt drug binding and those that increase...
This National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) project grant award of $967,980.00 to President and Fellows of Harvard College (doing business as Harvard Medical School) supports research on evolutionary tradeoffs in antibiotic resistance. The award, with a project period from February 1, 2025 to May 8, 2025, will enable laboratory studies to explore factors that influence the evolution of antibiotic resistance in...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) is focused on investigating "convergent evolution" in natural product biosynthesis as a potential approach to drug discovery. The $1,070,764 grant, awarded on August 1, 2024, supports research to identify and synthesize biologically-important natural product molecules, with the goal of developing new anti-cancer drug leads...
The National Institute of General Medical Sciences (NIGMS) awarded a $457,500.00 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Massachusetts Boston (UMass Boston). The grant, awarded on September 17, 2024, is funding a 3-year research project to systematically identify chemical processes that show promise when activated by high hydrostatic pressure (HHP). The research aims to build a comprehensive reaction network by performing...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training Program provides $1,256,250 in funding to the University of Massachusetts Medical School (UMass Medical) to support research on the mechanisms of internal ribosome entry site (IRES)-mediated translation and the impact of modified nucleosides on RNA structure and function. The key research objectives are to: 1) determine how IRES structural...
This $1,675,000 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms that regulate different forms of regulated cell death. The award will enable the University of Massachusetts Medical School to study how various cell death pathways, including apoptosis and regulated necrosis, interact and coordinate with each other. The researchers will use new...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,675,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Massachusetts Medical School (UMass Medical) to support research focused on two key areas of mammalian nuclear cell biology. The first project involves investigating the role of the tumor marker protein Ki-67 in protecting chromosomes from mitotic damage. Researchers will analyze how Ki-67 binds to and protects DNA, and map...
This federal Project Grant award of $1,203,701.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research program aimed at improving drug development processes. The program has three main focus areas: Developing ATP-allosteric bivalent inhibitors (AABIs) to selectively target the inactive state of human protein kinases, enabling rapid identification of promising new drug targets. This includes tailoring...
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development of advanced computational frameworks to enhance understanding of pharmacogenomic mechanisms in complex diseases. Over the 5-year award period from September 2024 to August 2029, the key products and services to be delivered include: 1) deep learning models that integrate multi-omic data to...