Project Grant R35GM156460
Award Date
9/1/25
Completion Date
8/31/30
Dollars Obligated
$492K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $415,252 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, Berkeley (UC Berkeley) for the project "PHYSICAL BIOLOGY OF TRANSCRIPTIONAL CONTROL IN EMBRYONIC DEVELOPMENT". The overarching goal is to leverage knowledge about regulatory regions and transcription factors to develop a predictive understanding of the developmental program...
This federal Project Grant award of $147,656 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a research project entitled "Examining the Conditionality and Time Dynamics of Evolutionary Constraint in Yeast." The project leverages high-throughput microbial experimental evolution lineage tracking methods to generate quantitative insights into the dynamics of evolutionary constraint. Specifically,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), will provide $403,750.00 to Duke University to conduct research on the structure, function, and evolution of gene regulatory networks in archaea. The project aims to use an integrated experimental and computational systems biology approach to characterize the architecture and dynamic function of transcriptional...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $550,108 to the University of California, Merced to conduct research on the genetic regulation of microbial community formation, particularly in the context of biofilms. The research aims to enhance understanding of how transcriptional networks regulate gene expression during biofilm development, including in fungi,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $507,000.00 in funding to the University of California, Davis to conduct research on evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila. The key objectives are to: 1) identify transcriptome novelties in Drosophila melanogaster reproductive tissues and investigate their functions,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $227,435 to the University of Rochester to conduct research on "Genetic Constraints on Adaptive Evolution". The goal is to unravel how genetic constraints limit adaptation and how these constraints diverge between species, building on the awardee's previous work characterizing constraints on thermal adaptation and...
This federal Project Grant award of $616,786, awarded on June 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at uncovering the evolutionary mechanisms shaping genetic variation and phenotypic diversity across human populations. The key focus areas of the research include: 1) exploring the effects of recessive deleterious alleles and associative overdominance on patterns of...
This $372,263 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will support research on the evolution of retrotransposon control mechanisms. The project aims to expand on the discovery of a self-encoded form of copy number control for the canonical Ty1 retrotransposon element in Saccharomyces yeast, and systematically investigate whether other Ty retrotransposon families undergo similar forms of...
This federal Project Grant award of $469,500.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research on cell-cell signaling and pattern formation in the model organism Saccharomyces cerevisiae (yeast). The primary objectives are to determine: 1) the role of signaling pathways and transcription factors in regulating differential partitioning of meiotic and feeder cells within yeast colonies in response to...
This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) provides $1,031,008 to St. Jude Children's Research Hospital Inc. to conduct research on dissecting the contributions of phase separation to yeast transcription. The primary objectives are to: 1) examine how transcription factors, coactivators, and DNA phase separate together and how multivalent interactions and solubility contribute to their...