Project Grant R35GM156229
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $659,591 to the University of Arizona to conduct research on the Target of Rapamycin Kinase Complex I (TORC1) signaling network in the yeast Saccharomyces cerevisiae. The research aims to (1) determine how TORC1 is driven into an intermediate signaling state in poor nutrient conditions, and (2) investigate how TORC1...
- The National Institute of General Medical Sciences (NIGMS) awarded a $366,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Central Michigan University. The grant, which runs from January 1, 2025 to December 31, 2029, aims to develop bioluminescent kinase sensors to monitor and manipulate cell signaling processes related to cell growth, division, and the cell cycle. The proposed research seeks to create novel tools for studying cell biology and...
- This Project Grant award of $423,500.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Utah to uncover fundamental cell signaling mechanisms that can be therapeutically targeted in disease. The award, with a performance period from July 1, 2025 to June 30, 2030, focuses on two key projects: Addressing the regulation and function of kinases in the "dark...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $620,934 project grant to the Regents of the University of Michigan to conduct research on the structure and function of human membrane cytochrome P450 enzymes. This 5-year grant, commencing on September 1, 2025, aims to generate initial X-ray structures and corresponding biochemical information on a selected set of validated disease-related P450...
- This federal Project Grant award of $123,737.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance drug discovery for protein domains containing intrinsically disordered regions. The award was granted to the Regents of the University of Michigan, a prominent U.S. state government-owned educational institution, with a performance period from October 1, 2024 to April 30, 2025. The NIGMS...
- This federal Project Grant award of $237,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the upstream regulation of mitochondrial bioenergetics by the mitochondrial acyl carrier protein (MTACP). The research aims to uncover how MTACP, which sits at the intersection of nutrient inputs and energy expenditure in mitochondria, is regulated through the 4'-phosphopantetheine...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $421,600 to The Morgridge Institute for Research, Inc. to understand how metabolic conditions influence the behavior of human cells. The key products and services to be delivered under this 5-year award include: Elucidating genetic and environmental contributions to human cell fitness and growth, leveraging innovative tools such as a...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- The National Institute of General Medical Sciences (NIGMS) awarded a $609,493 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sloan-Kettering Institute for Cancer Research. The grant, awarded on June 1, 2025 with a final completion date of May 31, 2030, supports fundamental scientific research to unravel the molecular mechanisms underlying lipid and energy storage in eukaryotic cells. Key objectives include: 1) elucidating the structure, function,...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $388,701 Project Grant to the Regents of the University of Michigan to conduct research on the non-canonical roles of AMPK and TBK1 in amino acid sensing by the mTOR signaling pathway. This 5-year research project aims to define how the energy-sensing kinase AMPK supports mTORC1 signaling and function in specific cellular contexts, rather than universally opposing it, which would represent a paradigm shift in the understanding of AMPK and mTOR regulation. The research will also investigate the contribution of the innate immune kinase TBK1 to mTOR signaling, tumor development, and glycemic control during obesity. The findings from this basic science research project have the potential to provide new insights into the integrated regulation of cellular homeostasis and inform the development of therapeutic strategies targeting dysregulated mTOR signaling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.7k | 8/7/25 |