The National Institute of General Medical Sciences (NIGMS) awarded a $2,070,444 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Chicago to characterize the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens. The research program will explore the effects of natural selection and genetic ancestry on gene expression, epigenetic traits, and immune responses to infection across diverse human populations....
The National Institute of General Medical Sciences (NIGMS) awarded a $1,380,568 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Chicago. This 5-year grant, effective August 1, 2024, supports an interdisciplinary research project to develop a predictive, multi-scale understanding of how cells adapt to changes in their environment. The project has three main scientific thrusts: 1) Studying the adaptive roles of stress-induced...
This $393,093 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to uncover the interaction between gene expression, cell morphology, and tissue-level mechanics in embryonic development. The principal investigator, Bianca Dumitrascu, will leverage an integrative statistical machine learning framework to analyze 4D data on mammalian development across multiple species,...
This $382,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate how spatial organization of glycan ligands influences glycobiology processes on the cell membrane. The project aims to integrate microscopy, spectroscopy, and computational modeling to unravel the microscopic binding mechanisms of lectin-glycan interactions. It will also explore approaches to control...
The National Institute of General Medical Sciences (NIGMS) awarded Dartmouth College a $409,896 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to develop new statistical methods and analyses leveraging functional genomics data to understand the effects of genetic variants and their roles in diseases. The project aims to: (i) identify response expression quantitative trait loci (eQTLs), (ii) detect disease-critical cell states using single-cell chromatin...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of novel statistical and computational methods for genetic epidemiology. The $346,582 award, active from January 1, 2025 to December 31, 2029, aims to address limitations in current computational approaches for leveraging pathogen genetic data in the study and surveillance of infectious diseases....
The National Institutes of Health's National Institute of General Medical Sciences (NIGMS) awarded a $380,587 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Johns Hopkins University for the project "Defining a Biophysical Basis for Cell Types, Cell States and Cellular Heterogeneity at Single-Cell Resolution." The project aims to develop new integrated technologies to investigate how distinct molecular programs drive cell behaviors and cellular...
The National Institute of General Medical Sciences (NIGMS) awarded a $395,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Utah State University to investigate the role of structural variants (SVs) in trait variation and adaptive evolution across three insect systems: Timema stick insects, Callosobruchus maculatus seed beetles, and Lycaeides butterflies. The research will combine genomic data, population genomics, and computational modeling to elucidate the...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $1,112,547 in funding to Texas A&M University over a 5-year period from July 1, 2024 to June 30, 2029. The award supports research to understand the molecular-level function and assembly of type IV pili (TFP), which are bacterial nanomachines involved in various virulence factors in the opportunistic pathogen...
This $1,044,566 Project Grant award was made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to Arizona State University (ASU). The funding will support ASU's research to develop machine learning models for studying protein interactions in the context of immune receptors. The research aims to 1) improve embedding techniques for representing biological sequences as numeric vectors, and 2) apply these embedding...