This federal Project Grant award for $1,188,381.00, made by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to harness evolutionary adaptation to identify novel molecular mechanisms modulating the environmental stress response. The research will focus on studying protein-level mechanisms regulating cytoprotective programs in animal specialists, such as fishes, whales, and birds, that have evolved to survive chronic hypoxia and oxidative stress. By reverse engineering these animal systems, the program seeks to reveal novel strategies capable of modulating the NRF2 and HIF-1 axis in human diseases where they are dysregulated. The award was made to Vanderbilt University, a leading research institution, and is set to run from July 2024 to May 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $396.1k | 5/19/25 | ||
| Not listed | $396.1k | 7/18/24 | ||
| Not listed | $396.1k | 7/18/24 |