Project Grant R35GM155035
- This $249,793 Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences program supports the development of new ruthenium-based chemical tools to study the biological role of the gaseous signaling molecule hydrogen sulfide (H2S). The research team at the University of California, Santa Barbara aims to leverage the redox and photochemical properties of ruthenium coordination complexes to create H2S-releasing agents that can...
- Federal Project Grant Award Summary The University of Oregon received a $398,464 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 6, 2026, with a completion date of December 31, 2030. This R35 award supports a five-year research initiative focused on developing innovative chemical tools and strategies to modulate reactive sulfur species (RSS), including hydrogen sulfide...
- Federal Project Grant Award Summary Entox Sciences, Inc. received a $613,734 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 4, 2025, with completion expected by September 3, 2026. The award supports the development and commercialization of instrumentation and technology for rapid control and assessment of dissolved gas signals in biological tissue samples....
- Federal Project Grant Award Summary Exhalix, LLC received a $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective September 16, 2025, through September 15, 2026. The award supports preclinical development of GENIE:S, an on-demand hydrogen sulfide (H2S) synthesis and delivery platform technology designed to treat peripheral artery disease (PAD) and chronic limb-threatening ischemia (CLTI). The platform addresses a critical...
- This Project Grant award of $432,834 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) with a performance period from April 15, 2025 to March 31, 2028. The objective is to develop an enzyme-free, label-free quantitative microarray technology to accurately measure and quantify small nucleic acid targets such as microRNA in the attomolar range for applications like liquid biopsy. The research...
- This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $500,000 in funding to The Regents of the University of Colorado to develop a suite of fluorescent RNA-based biosensors for monitoring metabolites in the methionine cycle of one-carbon metabolism in live cells. The project aims to create a "plug-and-play" toolkit of biosensors that can be used to study the dynamics and flux of central metabolites involved in regulating...
- This Project Grant award from the National Science Foundation's Integrative Activities (IA) program provides $275,000 to Clemson University to develop a flexible, tunable voltammetric sensor that can rapidly detect and quantify virulence signals from the Pseudomonas aeruginosa bacteria. The goal is to enable faster determination of infections caused by antibiotic-resistant bacteria, which annually lead to more than 35,000 deaths in the U.S. despite widespread antibiotic availability. The...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) provides $450,000.00 to the University of Texas at Austin over the period of January 1, 2025 to December 31, 2027. The project aims to develop novel biosensing tools for therapeutic drug monitoring, specifically for the antipsychotic medication clozapine. The key products and services to be delivered include: Selection and optimization of DNA/RNA aptamers that bind strongly and...
- This National Science Foundation (NSF) Project Grant award for $380,074, awarded on September 1, 2024, aims to develop a platform for instrument-free, easy-to-interpret quantitative analysis of molecular biomarkers. The project will produce a general methodology adaptable to a range of molecular targets, including potential new agents. The key products to be delivered include: A "yes/no" output for quantitative measurement, enabled through stoichiometry and negative cooperativity-based...
- Federal Project Grant Award Summary Aptus Biosciences LLC received a $356,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with a completion date of September 14, 2026. The award supports the development of chemically modified deoxyribonucleic acid (DNA) aptamers for rapid and accurate sepsis diagnosis. This research addresses a critical clinical gap: current...
BIOMEDICAL APPLICATIONS OF REACTIVE SULFUR AND SELENIUM SPECIES: DIAGNOSIS AND THERAPUETICS - PROJECT SUMMARY/ABSTRACT REACTIVE SULFUR SPECIES (RSS), INCLUDING HYDROGEN SULFIDE (H2S), PERSULFIDES (RSSH), AND POLYSULFIDES (RSSNR, N>1), ARE ENDOGENOUSLY EXPRESSED BIOMOLECULES THAT PLAY AN IMPORTANT ROLE IN HUMAN HEALTH AND DISEASE. FOR EXAMPLE, THE BIOLOGICAL ACTIVITY OF THE MOST PROMINENT MEMBER OF THIS CLASS OF COMPOUNDS, H2S, HAS BEEN SHOWN TO INCLUDE ANTICANCER ACTIVITY, NEUROPROTECTION, VASCULAR RELAXATION, HORMONAL REGULATION, AND ENERGY PRODUCTION. GIVEN THESE EFFECTS, IT COMES AS NO SURPRISE THAT RSS SUPPLEMENTATION IS BEING EXPLORED WITH GREAT INTEREST IN PRECLINICAL MODELS OF HUMAN ILLNESSES, INCLUDING CANCER, PARKINSON'S AND ALZHEIMER'S DISEASE, CARDIOVASCULAR- RELATED PATHOLOGIES, AND OTHER AGE-RELATED ILLNESSES. HOWEVER, DUE TO THEIR HIGH REACTIVITY AND SHORT HALF-LIFE, THE EFFECTIVE DELIVERY AND DETECTION OF RSS IS EXTREMELY CHALLENGING. THUS, RSS HAVE UNTAPPED POTENTIAL WHEN IT COMES TO THE DIAGNOSIS AND TREATMENT OF DISEASE. IN A SIMILAR FASHION, REACTIVE SELENIUM SPECIES (RSES), SUCH AS HYDROGEN SELENIDE (H2SE) AND HYDROSELENOSULFIDES (RSESH AND RSSEH), HAVE BEGUN TO ATTRACT SIGNIFICANT ATTENTION FROM THE CHEMICAL BIOLOGY AND MEDICINAL CHEMISTRY COMMUNITIES DUE TO THEIR PURPORTED THERAPEUTIC PROPERTIES. HOWEVER, THE BIOLOGICAL ACTIVITY OF THESE SELENIUM CONGENERS IS NOT WELL DOCUMENTED DUE TO SIMILAR INADEQUACIES WHEN IT COMES TO THEIR DELIVERY AND DETECTION. THEREFORE, THE WORK DESCRIBED IN THIS PROPOSAL IS SIGNIFICANT AS IT SEEKS TO OVERCOME THESE BARRIERS BY IMPLEMENTING NEW AND INNOVATIVE CHEMISTRY THAT WILL HARNESS THE REACTIVITY OF RSS AND RSES TO HELP REALIZE THE BIOMEDICAL APPLICABILITY OF THESE MOLECULES FOR BOTH THE DEVELOPMENT OF NOVEL THERAPEUTICS, INCLUDING SMALL MOLECULE DONORS (OR RSS/RSES RELEASING COMPOUNDS) WITH IMPROVED PROPERTIES (ORGANELLE-TARGETING, PATHOLOGY-SELECTIVE ACTIVATION, SELF-REPORTING FEATURES FOR MONITORING DONOR PROGRESS AND TRAFFICKING, AND NOVEL CO-DRUG DESIGNS FOR IMPROVED ACTIVITY AND/OR CHEMOPROTECTIVE EFFECTS) AND DIAGNOSTICS (REACTION-BASED FLUORESCENT SENSORS AND RSS/RSES-TRIGGERED THERANOSTICS). THIS CONTRIBUTION WILL BE INNOVATIVE AS IT IS EXPECTED TO OPEN THE DOOR TO NEW APPROACHES FOR THERAPEUTIC INTERVENTION INVOLVING BOTH RSS AND RSES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $363.8k | 5/21/25 | ||
| Not listed | $363.8k | 7/22/24 | ||
| Not listed | $363.8k | 7/22/24 |