Project Grant R41GM161234
- The federal Project Grant award of $731,827 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting research conducted by the J. David Gladstone Institutes in San Francisco, CA to investigate the mechanisms of oxygen toxicity. The key objectives include: 1) testing whether specific molecular pathways (diphthamide synthesis, de novo purine synthesis, and mitochondrial electron transport chain) are necessary and sufficient for impaired cell...
- This federal Project Grant award of $427,625 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop capillaric microfluidics for integrated sample preparation in miniaturized mass spectrometry (mini-MS) systems. The research will focus on creating portable, self-powered, and self-regulated sample preparation capabilities to improve the versatility and applicability of mini-MS instruments for...
- This federal Project Grant award of $348,963.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental scientific research to investigate the mechanisms of quorum signal synthesis in gram-negative bacteria, with the goal of establishing molecular determinants for substrate recognition and developing quorum sensing inhibitors as potential anti-virulence compounds. The...
- This $302,671 federal Project Grant awarded on August 2, 2025 by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to Andson Biotech Inc. aims to develop an innovative real-time mass spectrometry platform for in-process monitoring and cell state analysis of advanced cell therapies. The project seeks to address the challenges of variable quality and efficacy in cell therapies by enabling real-time measurement and control of critical...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
- This Project Grant award, ID R35GM156443, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $419,375 award, spanning January 1, 2025 to November 30, 2029, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to define the functional dynamics of multidomain redox enzymes, with a focus on nitric oxide synthase (NOS) enzymes. The research aims to gain a comprehensive...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to expand the capabilities and streamline the workflow of nuclear magnetic resonance (NMR) spectroscopy for biological research. The $489,500 award, granted on August 1, 2025, supports the development of new methods to extend the size limits of observable systems, improve sensitivity through advanced noise reduction, and...
- This Project Grant award, valued at $379,394.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project investigating the mechanisms by which human cells detect and respond to oxidative stress, with a focus on understanding the dose-dependent activation of key stress response proteins. The research aims to uncover how dynamic stress response pathways influence cell...
This federal Project Grant award of $306,867 from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) supports the project "RAPID CONTROL AND ASSESSMENT OF DISSOLVED GAS SIGNALS ON TISSUE FUNCTION AND DISEASE" at Entox Sciences, Inc. in Seattle, WA. The project aims to develop instrumentation and methods to rapidly control and assess the effects of biologically important gases, including hydrogen sulfide, nitric oxide, carbon monoxide, and oxygen, on biological samples. This research is intended to address a critical need to test the physiological effects of these signaling gases, as previous work has shown significant differences between the effects of gases and commonly used aqueous donor molecules. The project period runs from September 4, 2025 to September 3, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $306.9k | 9/3/25 |