Project Grant R35ES035028
- Federal Project Grant Award Summary The University of Southern California received a $616,715 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), with an award date of August 1, 2025 and completion date of May 31, 2030. This award funds research investigating nuclear actin filaments and phase separation as drivers of heterochromatin repair mechanisms. The research addresses how cells repair double-strand...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health program (CFDA 93.113), awarded a $2.98 million Project Grant to The Johns Hopkins University for research investigating epigenetic mechanisms that enhance transcriptional responses to environmental heat stress. Obligated on September 15, 2025, with a completion date of September 14, 2029, this four-year research initiative focuses on understanding how chromatin architecture...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a Project Grant of $385,000 under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research investigating the rules governing three-dimensional (3D) genome folding in single cells. The award, initiated March 1, 2026, and extending through December 31, 2030, funds the principal investigator's research program to...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Johns Hopkins University a $155,000 Project Grant on August 22, 2025, through the Environmental Health program (CFDA 93.113) to support research infrastructure and tool development for the Caenorhabditis Natural Diversity Resource (CaeDR). The grant funds Dr. Michael Sauria, a Research Software Engineer (RSE) in the Andersen Lab, to oversee critical computational and technical improvements to...
- This $440,000 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports research at Northwestern University to create an unbiased and global map of the cellular response to environmental proteotoxic stress. The project will integrate cutting-edge chemical-genetic screening with computational analysis to identify critical components, functions, and regulatory nodes in the proteostasis network that cells...
- Summary of Federal Project Grant Award The University of Pennsylvania received an $821,373 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) effective August 1, 2025, through May 31, 2030. This award funds research into cell-free DNA (cfDNA) methylation patterns and mitochondrial therapeutics in a rodent model of organophosphate poisoning. The project addresses significant public health concerns related...
- Federal Grant Award Summary Duke University received a $1,006,211 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective February 17, 2026 through January 31, 2034. The award supports research to understand how environmental exposures affect mitochondrial function and health, with particular emphasis on mechanisms of mitochondrial toxicity and their interactions with genetic mitochondrial disease. The...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant of $2,117,247 to The Leland Stanford Junior University, effective September 11, 2025, through August 31, 2029, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research into the genetic basis of complex traits, spanning evolutionary organisms from archaea and yeast to humans. The funded research will develop and apply...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded Harvard T.H. Chan School of Public Health a Project Grant valued at $168,316 on May 19, 2025, under the Environmental Health program (CFDA 93.113). The grant supports research investigating the biological mechanisms underlying children's heightened vulnerability to lead-induced neurotoxicity, with particular focus on the role of apoptosis (programmed cell death) in neural tissue. The research will...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Leland Stanford Junior University a Project Grant of $227,820 under the Biomedical Research and Research Training program (CFDA 93.859) for postdoctoral research investigating the evolutionary mechanisms of hybrid incompatibilities in Xiphophorus fish species. Initiated on August 10, 2026, and concluding February 28, 2029, the research project examines the repeated evolution of melanoma in hybrid...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $699,950 Project Grant to The Leland Stanford Junior University effective April 1, 2026, through March 31, 2034, under the Environmental Health program (CFDA 93.113). The research project, titled "Cellular Responses to Environmentally Driven Replication Stress," delivers fundamental scientific research investigating how environmental genotoxins induce DNA damage and create barriers that stall replication forks, leading to replication stress. The award supports advanced research combining molecular, biochemical, genomic, and proteomic approaches alongside state-of-the-art single-molecule techniques to examine cellular mechanisms for responding to genotoxic and oxidative damage. Specifically, the funded research focuses on replication fork reversal—a critical cellular response process in which ATP-dependent translocases remodel DNA strands to form protective four-way junction structures. The project investigates the function and mechanism of the HLTF translocase in preventing error-prone DNA synthesis modes and maintaining genome stability in response to environmental damage. Expected research products include mechanistic insights into replication fork reversal processes, an understanding of HLTF's regulatory functions, and knowledge of how loss of fork reversal affects genome stability and cell fitness. These research outcomes directly support NIEHS's mission to translate environmental health knowledge into strategies reducing disease burden and promoting human health by advancing understanding of how environmental exposures affect biological systems.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $700.0k | 3/31/26 |