This Project Grant award, titled "DROSOPHILA NSE5/6: A MISSING LINK FOR HETEROCHROMATIN REPAIR", is funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. The $456,500 award, effective from April 1, 2025 to March 31, 2027, supports research at the University of Southern California (USC) to identify and characterize the Drosophila NSE5/6 protein and its role in heterochromatin repair mechanisms. The...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $568,113 to support research investigating variant chromatin structures in eukaryotic cells. The award, which runs from February 1, 2025 to January 31, 2030, is led by the Research Foundation for the State University of New York, doing business as Stony Brook University. The key focus areas of the research include: 1) understanding...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to investigate the effects of polyamines on chromatin function and their impact on cell fate and chromatin homeostasis. The 5-year, $411,250 award to The Trustees of Columbia University in the City of New York will enable the principal investigator to explore how changes in intracellular and extracellular polyamines...
This Project Grant award of $749,901, funded by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, aims to elucidate the origins of the mutational landscape in cancer. The research project will integrate cellular DNA adductomics, nanopore sequencing, and single-molecule duplex sequencing to investigate how exposure to environmental mutagens, such as 1,2,3-trichloropropane, bromochloroacetic acid, and furan, contributes to the...
The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $667,480 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. on May 1, 2025. The grant supports a 5-year research project focused on studying the structural and functional dynamics of chromatin, which plays a critical role in cellular processes like gene expression, DNA replication, and cell differentiation. The research aims to advance the understanding...
This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Cause and Prevention Research program (CFDA 93.393), provides $541,682 to The Trustees of Columbia University in the City of New York for a 5-year period from July 3, 2024 to June 30, 2029. The project aims to better understand the mechanisms responsible for the assembly of DNA repair domains in cancer cells and evaluate the consequences of these domains following treatment with chemotherapeutic drugs....
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $200,000 in funding to The Trustees of the University of Pennsylvania to conduct collaborative research that aims to understand genomic organization in the cell nucleus. The research team will employ an integrated approach leveraging biophysical modeling, super-resolution imaging, and machine learning to develop predictive models of how chromatin structure and...
This Project Grant award of $160,330, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) federal grant program, supports research to investigate the biochemical determinants of genome instability induced by eukaryotic topoisomerase II. The research aims to understand how the biochemical properties of topoisomerases, along with other factors like chromatin structure and DNA repair pathways, contribute to genome instability. Key project...
This Project Grant award of $380,495.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks, which can lead to the formation of de novo structural variants in the germline. The research program at the Regents of the University of Michigan will address how closely spaced double-strand...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...