Project Grant R35ES034988
- Federal Project Grant Award Summary The University of Illinois received a $452,945 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) on September 8, 2025, with a completion date of August 31, 2027. This award funds research investigating how environmental chemical exposures modulate the ovarian lipidome and its relationship to infertility. The project will deliver a spatial ovarian lipidome map of human...
- Federal Project Grant Award Summary Midwestern University received a $521,992 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective September 1, 2025, through August 31, 2028. The award supports a research initiative titled "Dissecting the Role of LRH1 in Phthalate-Related Reproductive Impairments: A Cellular and Molecular Approach," which investigates how phthalate exposure during...
- Federal Grant Award Summary The University of Illinois received a $445,719 Project Grant awarded on September 15, 2025, through the Trans-NIH Research Support program (CFDA 93.310) administered by the National Institutes of Health Office of the Director. The grant supports a 24-month research initiative (through August 31, 2027) investigating the relationship between phthalate exposure, oxidative stress, and hot flashes in aging women. Building on preliminary findings from a cohort of 782...
- Federal Project Grant Award Summary The University of Illinois received a $440,908 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 1, 2025, through August 31, 2027. The award funds research to develop and validate engineered in vitro liver models that replicate pregnancy-induced physiological changes. The research utilizes high-throughput droplet...
- Federal Grant Award Summary The National Institute of Environmental Health Sciences (NIEHS) awarded $2.74 million to the University of Illinois under the Environmental Health program (CFDA 93.113) as a Project Grant to investigate the neurodevelopmental impacts of phthalate exposure on social behavior circuits. The award, obligated on September 15, 2025, with a completion date of September 14, 2029, funds research examining how developmental exposure to phthalates—common endocrine-disrupting...
- Federal Grant Award Summary The University of Illinois received a $600,000 Project Grant from the National Science Foundation (NSF) Engineering program (CFDA 47.041), awarded October 1, 2025, with completion scheduled for September 30, 2028. This BRITE PIVOT research initiative develops novel engineering tools to integrate spatial transcriptomics, multiplexed protein profiling, and mechanical characterization methodologies—specifically combining spatial omics data with mechanical and imaging...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $444,125 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded February 17, 2026, with completion targeted for February 16, 2028. The project delivers an integrated computational and experimental workflow to identify endocrine-disrupting plastic additives through machine learning and laboratory validation....
- Federal Project Grant Award Summary The University of Illinois received a $108,512 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded May 16, 2025, with completion scheduled for May 15, 2027. The award supports basic biomedical research investigating the mechanisms by which Salt-Inducible Kinase 3 (SIK3) regulates fertility in ovarian granulosa cells. The...
- Federal Project Grant Award Summary The University of Pennsylvania received a $124,728 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded September 8, 2025, with completion targeted for August 31, 2027. This research project investigates the mechanisms through which gestational and childhood exposure to endocrine-disrupting chemicals (EDCs)—including polybrominated diphenyl ethers, organophosphate...
- Federal Project Grant Award Summary The University of Texas at Austin received a $124,808 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective August 25, 2025, with completion targeted for July 31, 2027. This research project investigates how environmental endocrine-disrupting chemicals (EDCs) disrupt dopamine pathways in the brain's reward system, leading to behavioral and cognitive...
The University of Illinois received a $929,307 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), effective February 18, 2026, through January 31, 2034. This research initiative investigates the mechanisms by which endocrine disrupting chemicals (EDCs) damage the ovary and impair female reproductive function. The project delivers research products including single-cell RNA sequencing analyses to identify novel EDC-induced toxicity pathways, spatial transcriptomics mapping of gene activity changes while preserving tissue context, advanced three-dimensional ovarian follicle culture techniques, and state-of-the-art liquid chromatography-mass spectrometry (LC-MS) detection and quantification of EDC concentrations in female reproductive organs. The research program will generate additional scientific products through pioneering in vitro and in vivo experiments testing environmentally relevant individual EDCs and EDC mixtures, high-resolution proteomics analysis, and whole genome methylome characterization. The project bridges laboratory discovery to human health outcomes by examining EDC exposure associations with ovarian function and reproductive aging in a prospective cohort of midlife women. These research products collectively address urgent clinical and public health needs by elucidating mechanisms of EDC-induced reproductive toxicity and supporting the development of prevention and treatment strategies for EDC-related reproductive dysfunction.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $929.3k | 2/18/26 |