Cross-species conservation of inhibitory cell type contributions to visual cortical function
Ended Project Grant Awarded Last action
- Award ID
- R34NS137184
- Recipient
-
The Salk Institute For Biological Studies. San Diego. California UEI NNJ6BMBTFGN5
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,239,750
Award facts
- Assistance listing
- 93.867 Vision Research
- Completion date
- Funding agency
- National Eye Institute National Institutes of Health, Department of Health and Human Services
- Place of performance
- La Jolla, CA 92037, USA
Award details come from USAspending.gov.
Description
- Abstract
- The function of the nervous system is dependent on complex interactions between networks of neurons composed of multiple neuron types. Understanding how these networks function both in health and disease is dependent on understanding the precise connectivity between specific neuron types and their functional interactions in the intact brain. IT is therefore apparent that, in order to have an adequate understanding of the nervous system, IT is necessary to have detailed descriptions of neuronal connectivity with the same level of precision at which these systems operate and to selectively manipulate and measure the activity of specific cell types in the context of the normal functioning network. Such studies would be greatly facilitated by the ability to target gene expression to specific cell types in the context of AAV vectors. The aims of this proposal are designed to first test and overcome possible limitations in the use of AAV vectors targeting gene expression to SST- and PV-expressing inhibitory internueon in the visual cortex, and then to use these tools to selectively manipulate the activity and characterize the functions of these inhibitory subclasses. The establishment of the utility of these reagents will allow future studies testing the functional contributions of specific inhibitory neuron types to perception, cognition and behavior.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $42,750 | |
| Amendment | $384,750 | |
| Amendment | $384,750 | |
| Original award | $427,500 |
Quick answers
Who received award R34NS137184?
R34NS137184 was awarded to The Salk Institute For Biological Studies. San Diego. California by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on July 15, 2024.
How much is award R34NS137184 worth?
$1,239,750 has been obligated on R34NS137184.
Which agency awarded R34NS137184?
National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded R34NS137184, with funding from National Eye Institute (National Institutes of Health).
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award