The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
The U.S. National Institute on Aging (NIA) awarded a $134,000 project grant under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct a pilot study on a digital cognitive behavioral therapy for insomnia (DCBT-I) intervention for older adults undergoing orthopedic surgery. The goal is to evaluate the feasibility and efficacy of this abbreviated DCBT-I protocol in improving sleep and cognitive resilience...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and evaluate a culturally adapted sleep intervention program for older Korean immigrants with limited English proficiency. The $433,125 award will fund a 2-year pilot study, starting on February 1, 2025, to refine an existing cognitive behavioral therapy for insomnia (CBTI) program with input from stakeholders and Korean immigrants, and then conduct a randomized clinical trial to assess...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal of this Phase I project is to create a testable prototype that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful...
The National Institute on Aging (NIA) awarded a $780,466 Project Grant (CFDA 93.866 Aging Research) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, with a period of performance from December 15, 2024 to November 30, 2029. The goal of this project is to develop digital biomarkers using single-channel sleep electroencephalography (EEG) to monitor brain health and detect pathological aging and early neurodegenerative changes, such as those seen...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $383,400 to Dr. Minjee Kim at Northwestern University to investigate the role of sleep disturbance as a potentially modifiable determinant of cognitive impairment and Alzheimer's disease. The award will fund Dr. Kim's research to: 1) examine associations between sleep disturbance, cognitive function, self-care capacity, and health status in middle-aged adults; 2) develop sleep disturbance...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
The National Institute on Aging (NIA) awarded a $124,875 project grant (CFDA 93.866) to the Hebrew Rehabilitation Center in Boston, MA to study the effects of the home thermal environment on the health and well-being of low-income older adults. The 5-year grant, awarded on August 1, 2024, will continuously measure the home temperature conditions of 50 low-income older adults living in subsidized housing in Boston. Participants will use wearable devices to track sleep, gait, and self-reported...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $129,659 to The Johns Hopkins University to conduct a longitudinal study examining the relationship between physical activity, sleep, brain network connectivity/microstructure, and cognitive resilience in aging and preclinical Alzheimer's disease. The research aims to identify modifiable lifestyle factors and neuroimaging biomarkers that may enhance cognitive resilience and help elucidate the...
The National Institute on Aging (NIA) awarded a $537,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Incorporated) to culturally adapt and pilot a social network approach to deliver a sleep health and mindfulness program to cognitively unimpaired older adults in low-income housing in Boston. The project aims to improve sleep, quality of life, and cognitive function in this population, with the long-term goal of reducing Alzheimer's disease risk. This 3-year project will involve iterative user feedback, prototyping, and a feasibility/acceptability pilot study, in collaboration with the City of Boston Age Strong Commission, prior to a planned cluster randomized controlled trial in a future R01 grant application.