A multi-team system implementation strategy to improve buprenorphine adherence for patients who initiate treatment in the emergency department
Active Project Grant Awarded Last action
- Award ID
- R33DA059027
- Recipient
-
University Of California, Davis UEI TX2DAGQPENZ5
- Awarding agency
-
National Institute on Drug Abuse
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,311,565
Award facts
- Assistance listing
- 93.279 Drug Use and Addiction Research Programs
- Completion date 54% complete
- Place of performance
- Sacramento, CA 95817, USA
Award details come from USAspending.gov.
Description
- Abstract
- Drug overdose deaths continue to rise in the US due largely to opioid-related deaths, despite availability of buprenorphine, a highly effective treatment for opioid use disorder (OUD). Starting buprenorphine for OUD in emergency departments is an increasingly common practice across the US. A large clinical trial found that emergency department-initiated buprenorphine plus referral to primary care for ongoing treatment significantly increased buprenorphine treatment rates, but effects were not sustained past two months. Effective strategies to help patients start, restart, and sustain buprenorphine treatment are urgently needed to reduce overdose deaths. To increase buprenorphine treatment, california established CA bridge, a state-funded program in >200 hospitals that offers same-day buprenorphine initiation plus referral to primary care for patients with OUD who seek care in emergency departments. However, suboptimal care coordination persists, especially for low- income patients. This study's overarching hypothesis is that an implementation strategy that encourages coordination involving ongoing partnerships rather than one-time handoffs between emergency department and primary care teams will improve buprenorphine treatment and retention rates for patients who start buprenorphine in the emergency department. The objective is to refine an implementation strategy informed by multiteam systems theory that is focused on improving OUD care coordination between emergency department and primary care teams and then test this strategy in a hybrid type III effectiveness-implementation study using a stepped wedge design randomized at the site level. The R61 phase will involve collecting and analyzing data from two CA bridge sites to identify core and peripheral elements of this implementation strategy and develop an implementation strategy, a preliminary implementation blueprint, and data collection protocols for the R33 phase. The stepped wedge study during the R33 phase will involve four CA bridge sites. Implementation outcomes will include between-team coordinating activities and care transitions. Effectiveness outcomes will include rates of outpatient buprenorphine initiation (filling ≥1 outpatient prescription) and sustained buprenorphine treatment 3, 6, and 12 months after patients leave the emergency department, assessed with data from california's prescription drug monitoring program. Factors associated with successful implementation and sustainability will be identified through pre- and post-implementation interviews with patients, staff, and managers at each emergency department and primary care clinic and through engagement with relevant stakeholders, including patients, CA bridge statewide leadership and prospective payers. Study results will be used to develop an implementation blueprint that hospitals in california and across the US can use to improve OUD treatment outcomes for patients who start buprenorphine in emergency departments. This study will advance efforts to improve long-term buprenorphine treatment rates at scale for low-income and other vulnerable patients who disproportionately seek OUD care in emergency departments.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $1,155,365 | |
| Original award | $1,156,200 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Marshall Medical Center | $97,750 | |
| El Centro Regional Medical Center | $78,540 |
Quick answers
Who received award R33DA059027?
R33DA059027 was awarded to University Of California, Davis by National Institute on Drug Abuse (National Institutes of Health) on August 1, 2023.
How much is award R33DA059027 worth?
$2,311,565 has been obligated on R33DA059027.
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