Project Grant R33CA315144
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Jackson Laboratory a $704,636 Project Grant under the Cancer Biology Research program (CFDA 93.396) on May 14, 2026, for research titled "Pre-Leukemic Hematopoietic Stem Cell Clonal Selection by the Adaptive Immune System." This five-year project, concluding April 30, 2031, will deliver fundamental research on the mechanisms by which the adaptive immune system detects and selects hematopoietic stem and...
- Federal Grant Award Summary The National Cancer Institute awarded The Jackson Laboratory a $543,984 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, through May 31, 2031, to investigate the role of ZBTB7A in acute myeloid leukemia (AML) differentiation. The award funds in vivo animal studies using NSG-SGM3 mice and patient-derived xenografts to evaluate AML engraftment, disease progression, and therapeutic response—outcomes that cannot be adequately...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded The Jackson Laboratory $136,687 on July 15, 2026, to support research training and scientific investigation into the roles of ZBTB7 paralogs in leukemogenesis. This award supports a dual-phase training and research initiative aimed at understanding how tumor suppressor genes are inactivated at the post-transcriptional level in acute myeloid leukemia (AML) and...
- Federal Project Grant Award Summary The Jackson Laboratory received a $506,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) awarded March 1, 2026, with completion scheduled for December 31, 2030. The grant supports a five-year research initiative investigating the interplay between quaking (QKI) RNA-binding protein isoforms and N7-methylguanosine (M7G) RNA modifications in regulating...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Jackson Laboratory a $486,750 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) on August 15, 2025, with a completion date of July 31, 2030. This five-year award supports the development of a novel computational framework called Multi-Omics-Multi-Organ Sequencing (MOMO-SEQ) for investigating mammalian iron systems biology across multiple organ systems. The...
- Federal Project Grant Award Summary The Jackson Laboratory received a $155,269 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded March 1, 2026, with completion targeted for February 28, 2029. The grant funds the development and delivery of a Short Course on Spatial Transcriptomics (ST) at the Jackson Laboratory's Bar Harbor, Maine facility. This four-day educational program addresses barriers to researcher...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $182,755.00 to Cold Spring Harbor Laboratory through the Cancer Biology Research program (CFDA 93.396) to support research on genetic technology development for elucidating lineage plasticity mechanisms in cancer. The project, which commenced on August 21, 2025, and is scheduled for completion on July 31, 2030, will deliver advanced genetic screening technologies and methodologies designed to probe lineage identity...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $270,683 on May 5, 2026, under the Cancer Biology Research program (CFDA 93.396) to the New York Genome Center, Inc. (NYGC) for the development and validation of Paired-Break-Seq, a novel single-cell multiomics sequencing technique. This project, scheduled for completion on April 30, 2029, addresses a critical technical gap in cancer research by enabling simultaneous joint analysis of DNA double-strand breaks (DSBs),...
- Federal Grant Award Summary Cold Spring Harbor Laboratory received a $704,182 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded on June 16, 2026, with a completion date of May 31, 2031. The award funds fundamental research to elucidate the non-mutational mechanisms driving benign-to-malignant transition in colorectal cancer (CRC). The research employs a novel mouse model that recapitulates the stepwise acquisition of...
The Jackson Laboratory received a $452,458 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) beginning August 1, 2026 and extending through July 31, 2029. The award funds development and validation of enhanced tools for single-cell long-read sequencing isoform transcriptomics (SCLRSEQ) to enable robust mapping and analysis of full-length spliced transcriptional isoforms at single-cell resolution in tumor tissues. The project addresses a critical technical gap in cancer research by overcoming limitations of current single-cell long-read sequencing approaches, including suboptimal read length and depth, and the absence of bioinformatics pipelines customized for integrated single-cell and long-read sequencing data analysis. The research directly supports personalized cancer medicine by elucidating how alternative splicing dysregulation contributes to tumor heterogeneity and influences drug response and resistance. The project will rigorously validate the advanced SCLRSEQ platform using orthogonal validation methods, including fluorescent in situ hybridization and comparison to bulk short- and long-read sequencing data from sorted cells. Deliverables will include validated technological tools and associated bioinformatics infrastructure positioned for broad adoption in cancer molecular profiling and clinical applications targeting splicing vulnerabilities in cancer cells.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $452.5k | 7/16/26 |