Project Grant R35GM162347
- Federal Project Grant Award Summary The Jackson Laboratory received a $486,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 15, 2025, with a completion date of July 31, 2030. The award funds development of the Multi-Omics-Multi-Organ Sequencing (MOMO-SEQ) computational framework, a novel integrated analytical tool designed to investigate mammalian iron systems...
- Federal Grant Award Summary The National Institutes of Health Office of Research Infrastructure Programs (CFDA 93.351) awarded The Jackson Laboratory a $3.19 million Project Grant on April 15, 2025, for the development and establishment of a Wild Mouse Diversity Panel (WMDP), a novel outbred mouse population designed to advance precision mapping and systems genetics research. The award, which extends through March 31, 2029, addresses a critical limitation in current laboratory mouse models by...
- Federal Project Grant Award Summary The Jackson Laboratory received a $155,269 Project Grant from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), awarded March 1, 2026, with a completion date of February 28, 2029. The grant supports the development and delivery of a four-day Short Course on Spatial Transcriptomics (ST) designed to train researchers in the fundamentals, applications, and analysis methods of spatial transcriptomics...
- Federal Project Grant Award Summary The Jackson Laboratory received a $486,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2027. This award funds research investigating the impact of age-related clonal hematopoiesis (CH)—the age-dependent accumulation of somatic mutations in hematopoietic stem cells—on Alzheimer's disease (AD) pathology onset and progression. The primary...
- Federal Project Grant Award Summary The Jackson Laboratory was awarded $354,000 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective March 15, 2026, with a project completion date of March 14, 2028. This Project Grant funds the development of an automatable protocol for creating human induced pluripotent stem cell (iPSC)-derived microglia and their co-culture with primary astrocytes from Alzheimer's disease (AD) patients. The deliverable is a...
- Federal Project Grant Award Summary The Jackson Laboratory received a $716,579 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on December 15, 2025, with a completion date of November 30, 2030. The grant supports genetic dissection of microglia functions in complement-mediated synapse loss in Alzheimer's disease. The research employs a multi-modal genetic approach utilizing floxed alleles of multiple genes (CSF1R, TREM2, STING1, C1QA,...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a Project Grant totaling $776,042 (award date: May 1, 2025; completion date: February 28, 2030) under the Biomedical Research and Research Training program (CFDA 93.859) to support research investigating the roles of microRNAs (miRNAs) in animal development. The research program systematically examines how conserved miRNAs regulate gene expression during embryonic...
- Federal Grant Award Summary The Mount Desert Island Biological Laboratory received a $464,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with completion targeted for January 31, 2031. The award funds fundamental research exploring tissue-specific mechanisms and requirements for nucleolin (NCL) organization in living organisms, with a focus on understanding...
- Federal Project Grant Award Summary The Jackson Laboratory received a $601,272 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period August 1, 2025, through July 31, 2028. The project, "Revealing Spatial Transcriptomic and Proteomic Shifts in Tumor-Infiltrating Immunocytes: Charting a Path to Enhanced Melanoma Therapeutics," delivers advanced biomedical research services focused on characterizing...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Florida a Project Grant totaling $466,125 under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research on RNA localization and local translation mechanisms. The five-year project, initiated August 1, 2025 and concluding May 31, 2030, will be conducted at the University of Florida's Jupiter, Florida facility. The research leverages...
The Jackson Laboratory received a $506,000 Project Grant award dated March 1, 2026, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project, titled "Decoding the Interplay Between QKI and M7G Methylation on 3'UTR," will be conducted at the Jackson Laboratory's Farmington, Connecticut facility through December 31, 2030. This award supports fundamental research to investigate post-transcriptional gene regulation mechanisms by examining the interaction between quaking (QKI) isoforms and N7-methylguanosine (M7G) RNA modifications on messenger RNA three-prime untranslated regions during cellular differentiation. The deliverables from this five-year research project include: (1) development of novel methodologies for base-resolution detection of M7G methylation using direct RNA long-read sequencing and orthogonal approaches; (2) characterization of messenger RNA targets regulated by distinct QKI isoforms; and (3) functional analysis of QKI-M7G interactions in myeloid differentiation. The research outcomes are expected to advance understanding of RNA modification-driven gene regulation with broader implications for stem cell biology, neurodevelopment, and cancer research, contributing to the NIGMS mission of supporting basic biomedical research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.0k | 2/20/26 |