Project Grant R01CA311181
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Jackson Laboratory $486,750 under the Aging Research program (CFDA 93.866) for a two-year project beginning September 1, 2025, and concluding August 31, 2027. This Project Grant funds research investigating the impact of age-related clonal hematopoiesis (CH)—a condition in which blood-forming stem cells accumulate somatic mutations that provide selective growth advantages—on Alzheimer's disease (AD) pathology onset...
- Federal Grant Award Summary The National Cancer Institute awarded $138,846 to the University Health Network under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a two-year Project Grant commencing August 1, 2025 and concluding July 31, 2027. The award supports the development of laboratory-generated "wild-like" mouse models designed to enhance the translational relevance of preclinical cancer and immunotherapy research. The primary deliverable involves adapting...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $495,715 to the Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 5, 2025, with a completion date of July 31, 2030. This award funds fundamental research to decipher the pathogenesis and therapeutic vulnerabilities in germline RUNX1-mutated acute myeloid leukemia (AML). The research focuses on understanding how germline RUNX1 mutations...
- Federal Project Grant Award Summary The Jackson Laboratory received a $601,272 project grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), effective August 1, 2025, through July 31, 2028. The award supports research investigating spatial transcriptomic and proteomic shifts in tumor-infiltrating immunocytes to advance melanoma therapeutics. Under the principal investigator direction of Dr. Joshy George, the research will be conducted...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Jackson Laboratory a $486,750 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) on August 15, 2025, with a completion date of July 31, 2030. This five-year award supports the development of a novel computational framework called Multi-Omics-Multi-Organ Sequencing (MOMO-SEQ) for investigating mammalian iron systems biology across multiple organ systems. The...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1,034,176 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, for a project extending through July 31, 2032. The research focuses on understanding and targeting aberrant RNA splicing in leukemia, building on the principal investigator's 13-year track record of discovering genetic alterations in hematopoietic malignancies. The project aims to...
- Federal Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a $573,262 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective April 17, 2026, with completion targeted for March 31, 2031. The award supports the development of innovative autologous humanized patient-derived xenograft (PDX) models designed to advance preclinical testing of immunotherapies for...
- Federal Grant Award Summary The Jackson Laboratory received a $354,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 15, 2026, with a completion date of March 14, 2028. This award supports the development of an automatable protocol for creating human induced pluripotent stem cell (iPSC)-derived microglia and their co-culture with primary astrocytes to identify disease-associated expression quantitative trait loci...
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $484,405 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year award supports fundamental cancer biology research investigating NSD2 (Nuclear Set Domain Family Member 2) mutations and their role in driving acute lymphoblastic leukemia (ALL) transformation. The research...
- Federal Project Grant Award Summary The National Cancer Institute awarded $452,540 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for a project grant spanning May 1, 2026 through April 30, 2028. The funded research addresses innate and adaptive determinants of cytokine release syndrome (CRS) in chimeric antigen receptor (CAR) T cell therapies for hematologic malignancies. The project investigates the molecular mechanisms underlying CRS, a...
The National Cancer Institute (NCI) awarded The Jackson Laboratory a $704,636 Project Grant on May 14, 2026, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on pre-leukemic hematopoietic stem cell (HSPC) clonal selection by the adaptive immune system through April 30, 2031. The research deliverables include mechanistic studies defining the stages at which CD4+ T cells control pre-leukemic HSPC selection and evaluation of reduced interferon-gamma (IFNG) responsiveness as a mechanism enabling immune evasion of DNMT3A-mutant HSPCs. The project will generate scientific data and findings on immunological checkpoints in early leukemogenesis to identify immuno-preventative intervention strategies that intercept leukemia development at its earliest stages in aged populations. As a specialized biomedical research institution with extensive expertise in mammalian genetics and mouse model development, The Jackson Laboratory will leverage its capabilities to deliver experimental findings through in vitro and in vivo studies using mouse models, with research performed at its Bar Harbor, Maine facility. The research outputs are expected to contribute to the Cancer Biology Research program's objective of providing fundamental information on cancer causation and mechanisms to improve prevention, detection, and treatment methods for neoplastic diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $704.6k | 5/18/26 |