Project Grant R25HD118212
- The Children's Hospital of Philadelphia (CHOP) has been awarded a $1,029,350 project grant by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct a study titled "Cardiometabolic Risk and Comorbidities in Adults with Down Syndrome - Electronic Health Record Examination (CASCADE)". The study aims to: Describe the prevalence of type 2 diabetes, dyslipidemia, hypertension, and obstructive sleep apnea, as well as quantify HbA1c and lipid...
- The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,017,548 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of North Carolina at Chapel Hill. The grant, titled "HOME GROWN: A FAMILY-BASED LIFESTYLE INTERVENTION TO SUPPORT HEALTHY DEVELOPMENT OF YOUNG CHILDREN WITH DOWN SYNDROME," will fund a 2-phase study to evaluate the feasibility (R61 phase) and efficacy (R33 phase) of a tailored healthy...
- This $158,976 Project Grant was awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to The Children's Hospital of Philadelphia (CHOP) to investigate the mechanisms underlying hematopoietic disorders associated with Down syndrome (trisomy 21). The research aims to use a novel human induced pluripotent stem cell system to isolate the individual and synergistic roles of trisomy 21, the GATA1S transcription factor mutation, RUNX1 isoforms, and...
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $446,096 to the University of Illinois to develop and implement community-based participatory health research with young adults with Down syndrome. The project aims to reflect the perspectives and lived experiences of adults with Down syndrome, including those from underserved and underrepresented communities, to reduce health disparities and...
- The Children's Hospital of Philadelphia (CHOP) has been awarded a $415,245 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The grant will fund a natural history study and development of patient-centric clinical outcome assessments for Tubulin Beta 4A-Associated Leukodystrophy (TUBB4A-LD), a rare pediatric hypomyelinating disorder....
- The Project Grant award of $451,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding research at the University of Texas Southwestern Medical Center (UT Southwestern) to identify genes on human chromosome 21 that contribute to the neurological and developmental impairments associated with Down syndrome. The 2-year project will use CRISPR interference (CRISPRi) technology and induced pluripotent stem cells (iPSCs) derived from individuals...
- The Trustees of the University of Pennsylvania received a $3.7 million Project Grant award from the Department of Health and Human Services National Institutes of Health Office of the Director to address co-occurring conditions in individuals with Down syndrome. Funded under the Trans-NIH Research Support program (CFDA 93.310), the three-year project will test whether reducing proteostatic stress with the FDA-approved small molecule 4-phenylbutyrate can ameliorate sleep deficits, metabolic...
- The National Institute of Child Health and Human Development (NICHD) awarded a $163,813 Project Grant to the University of Colorado-Denver (UCD) for the project "Improving Health Care Communication and Engagement for Adults with Down Syndrome." The 5-year grant, starting on September 3, 2025, aims to address health disparities experienced by individuals with Down syndrome by developing and piloting a patient-and-supporter-driven communication tool tailored for adults with Down...
- This federal Project Grant award of $2,375,939.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding a research study on "Neural Markers of Late Language Emergence in Preschool Children Born Very and Extremely Preterm" at The Children's Hospital of Philadelphia (CHOP). The research aims to investigate the neural mechanisms underlying delayed language development in children born prematurely. The award was made on September 10,...
- This is a Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $419,615 grant will provide support for a 5-year collaborative postdoctoral clinical pharmacology training program between Children's Hospital of Philadelphia and Thomas Jefferson University. The program aims to train the next generation of drug development scientists by providing...
The Children's Hospital of Philadelphia (CHOP) received a $732,541 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310). The goal of this 24-month grant, awarded on August 7, 2025, is to develop a transdisciplinary training program to foster a new generation of investigators to pursue research in youth and adults with Down syndrome (DS). The PARTNERS program will provide a week-long in-person short course at CHOP, supplemented by online materials and monthly virtual meetings and mentorship. The training will cover topics such as DS and related co-occurring conditions, ethical and legal issues in DS research, engagement with patients and caregivers, data management and scientific rigor, and data analysis considerations. This comprehensive "whole-person" curriculum aims to address gaps in the availability of a transdisciplinary, collaborative workforce with expertise in clinical research involving individuals with DS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($1m) | 8/13/25 | ||
| Not listed | $1.9m | 8/1/25 |