Project Grant R25GM167082
- The National Institute of General Medical Sciences awarded the University of California, San Diego $211,433 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structural and biophysical principles governing protein-glycan interactions. The research program pursues three major objectives: defining the thermodynamic and structural basis of protein-glycan interactions at the atomic level to reveal how proteins achieve specificity within...
- The National Institute of General Medical Sciences awarded the University of California, Davis $675,667 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemoenzymatic strategies for synthesizing glycans and glycoconjugates. The research program focuses on two major directions: developing innovative chemoenzymatic methods for synthesizing complex bacterial surface glycans, including those with multiple polysaccharide repeating units applicable...
- The National Institute of General Medical Sciences awarded the University of California, Davis $402,051 on February 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct multi-glycomic characterization of cell membrane and protein-protein interactions. The research develops an automated platform for comprehensive glycomic analysis of N- and O-glycans on proteins and glycolipids, combining sample preparation and software for structural annotation to...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $384,394 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular determinants of lipid-protein recognition through computational and experimental approaches. The research integrates deep-learning, molecular dynamics simulation, and de novo protein design to characterize biophysical interactions governing binding affinity and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $833,955 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop tools for mapping the glycan-protein interactome using bioorthogonal chemistry and deep learning. The recipient will synthesize and optimize bifunctional ganglioside probes bearing photoaffinity diazirines and click alkyne tags, deliver these probes to human cancer cell lines to capture...
- The National Institute of General Medical Sciences awarded Duke University $474,507 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on cell signaling through O-linked glycosylation, with performance in Durham, North Carolina through March 31, 2031. The research focuses on O-linked β-N-acetylglucosamine (O-GlcNAc), a ubiquitous intracellular post-translational modification that decorates thousands of nuclear and cytoplasmic...
- Federal Project Grant Award Summary The University of California, San Diego (UCSD) received a $638,334 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 8, 2025, with a completion date of August 31, 2027. The award funds development of innovative computational drug design technologies through novel methods for thermodynamic mapping of proteins, ligands, and aqueous...
The National Institute of General Medical Sciences awarded $439,281 to the University of California, San Diego on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and deliver GLYCOCRAFT.EDU, a modular, experiment-based educational platform for glycoscience training. The platform addresses underrepresentation of glycan research in biomedical education by providing portable, hands-on training kits that enable researchers at all career stages to perform glycomics experiments in standard laboratory settings. The program delivers seven core experimental modules focused on fundamental techniques for glycan isolation and characterization, each combining interactive virtual instruction, structured hands-on experimentation, and iterative feedback. Participants will isolate and analyze glycans from biological specimens using standardized protocols and reagents provided in self-contained kits; upon completion of each module, samples will be submitted to UC San Diego's Glycobiology Research and Training Center Glycoanalytics Core for centralized analysis and expert consultation. The program builds on foundational glycoscience and glycobootcamp courses previously developed by the institution. Work is performed in La Jolla, California, with performance extending through March 31, 2031. The award is structured as a Project Grant, the assistance type used by NIGMS for investigator-initiated biomedical research and training.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.3k | 7/27/26 |