The National Institutes of Health (NIH) awarded the University of Iowa a $573,919 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to enhance the open-source distribution of monoclonal antibodies (mAbs) for research. The key objectives of this 4-year grant, awarded on April 15, 2025, are to: 1) develop new open-source non-rodent hybridoma methodology, 2) perform antibody validation for large, less well-characterized mAb collections to improve model organism research, and 3)...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $881,450.00 to the University of Massachusetts Medical School (UMass Medical) to develop novel humanized mouse models for engrafting human tissue-specific macrophage populations. The goal is to generate NSG mouse strains that are deficient in mouse tissue resident macrophages and express human cytokines to promote the development of human myeloid cells,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $415,329 to Northern Illinois University (NIU) to engineer and characterize pH-dependent antibodies. The research aims to explore methods to control antibody-antigen interactions through the introduction of acidic residues at the interface, with the potential to open new opportunities in antibody-based therapies....
This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) will fund the development of two novel mouse models at Cornell University. The $235,500 award, effective September 1, 2024 through June 30, 2026, will support the creation of a "unilateral mosaic" mouse model to study asymmetric disease pathology and a genetically-engineered mouse with a cell-tracing system to map cellular interactions in vivo. The...
This federal Project Grant award of $578,093 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research into the immunobiology of a novel human DAMP receptor and its murine homolog, including their ligand. The award was made to the University of Massachusetts Medical School (UMass Medical), a prominent research institution and medical school experienced in securing federal grants and contracts....
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $844,954 to New York University School of Medicine to develop "Genomically Rewritten and Tailored Humanized Mouse Models for Various Organ Disorders". The project aims to leverage advanced DNA synthesis and editing technologies to create mouse models that accurately reflect human disease genetics and phenotypes. These "GREAT-GEMMS"...
This $578,254 federal Project Grant award from the National Institutes of Health (NIH) Biomedical Research and Research Training Program (CFDA 93.859) supports research investigating the role of mitochondrial metabolism in regulating the differences in developmental rates observed across mammalian species. The research aims to leverage an in vitro system that replicates the accelerated development timelines of mouse embryos compared to human embryos, with a focus on uncovering the mechanisms...
This Project Grant award from the National Institutes of Health (NIH), under the Research Infrastructure Programs (CFDA 93.351), provides $775,888 to the La Jolla Institute for Immunology (LJI) to create and validate a modular CRISPR-ready HLA transgenic mouse platform. The goal is to develop a versatile mouse model that can be customized with different HLA class I and II alleles to study T cell responses across a broad range of diseases, from infectious diseases to cancer, autoimmune disorders,...
The National Institutes of Health (NIH) awarded a $340,302 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the Medical University of South Carolina (MUSC). The goal of this 1-year project, with a performance period from July 1, 2024 to June 30, 2025, is to modernize the microenvironment monitoring capabilities and increase the housing capacity of MUSC's animal research facility. This will be achieved by upgrading the obsolete animal caging system and integrating...
This $442,024 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports scientific research to elucidate the cellular mechanisms governing antibody effector functions. The award aims to establish quantitative relationships between antigen, antibody, and effector biology in order to develop design criteria for engineering antibodies with predictable effector profiles. This...