This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $442,024 to Trustees of Dartmouth College to conduct research on the molecular characterization and modeling of efficient antibody effector function. The research aims to elucidate the cellular mechanisms that drive advancements in the development of immune therapeutics and the parameters that influence the outcome...
The National Institute of General Medical Sciences (NIGMS) has awarded a $439,992 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Iowa State University of Science and Technology to develop synthetic mimics of enzymes and antibodies for binding and hydrolysis of complex biological targets such as glycans, peptides, and post-translationally modified proteins. The project, titled "Mimics of Enzymes and Antibodies for Glycans and Other Biological Targets," aims...
The Wistar Institute Of Anatomy And Biology was awarded a three-year, $3,232,020 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant will support research aimed at modulating epitope immunodominance and tracking B-cell antigen interactions to inform vaccine design against rapidly mutating viruses. Specifically, the grantee will develop novel strategies to...
The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $999,997 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to Ramona Optics Inc., a small disadvantaged business in Durham, North Carolina. The grant funds the development of the MCAM-3D, a novel microscope platform capable of parallelized, high-speed 3D imaging of unconstrained model organisms like zebrafish and Drosophila. The MCAM-3D system will integrate real-time...
This Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $781,525 to the University of California, Davis (UC Davis) from July 1, 2024 to June 30, 2029. The objective is to integrate cutting-edge in vivo imaging technologies and immunological assessments to enhance the rigor and reproducibility of translational nonhuman primate models for genetic and regenerative therapies. Specifically, the award will: Use...
This Project Grant award of $773,741.00, issued on August 20, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID), supports research aimed at defining and refining methods to enhance the antiviral activity of broadly neutralizing antibodies (bnAbs) against HIV. The research, conducted by Trustees of Dartmouth College, focuses on two key strategies: 1) improving bnAb antiviral activity through Fc engineering, and 2) evaluating the ability of bnAb combinations, with and...
The National Institutes of Health (NIH) awarded a $400,000 Project Grant under the Research Infrastructure Programs (CFDA 93.351) to the University of Colorado-Denver. The grant will enable the university's Human Immune Monitoring Shared Resource (HIMSR) core facility to acquire a state-of-the-art Lunaphore COMET high-parameter fluorescence imaging platform. This instrument will expand the facility's capacity to provide affordable, high-throughput multiplex tissue imaging services to a growing...
The University of Iowa was awarded a $1,354,009 Project Grant from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The grant, with a period of performance from September 1, 2024 to August 31, 2027, aims to develop clinically deliverable RNA strategies for radiation protection. The research project leverages the protective qualities of extremophile proteins and new delivery methods to reduce the impact of radiation-induced...
The Department of Health and Human Services (HHS) National Institutes of Health (NIH) awarded a $1,319,060 Project Grant to Duke University under the Trans-NIH Research Support (CFDA 93.310) program. The grant, effective September 1, 2023 through August 31, 2026, will fund research to study the robust formation of organs, with a focus on the development of the semicircular canals in the inner ear of zebrafish. The research aims to measure variations in tissue patterns, investigate the respective...
This $596,584 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to define the role of the NF-kB signaling network in generating long-lived plasma cells and memory B cells. The project aims to 1) determine how the NF-kB inhibitors IkBα and IkBε regulate the generation of long-lived plasma cells and memory B cells, 2) identify how cell surface receptors regulate the...