Project Grant R24GM165260
- The National Institute of General Medical Sciences awarded $343,351 to Arizona State University on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate plasmid DNA methylation in tissue repair. The research examines the delivery of unmethylated plasmid DNA (uPDNA) possessing differential prokaryotic methylation content to skin for transgene expression and tissue repair applications. Preliminary findings demonstrate that intradermal and...
- The National Institute of General Medical Sciences awarded Arizona State University $2,081,661 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop plasmonic and evanescent scattering microscopy technologies for label-free functional imaging of single molecular and cellular activities. The recipient will advance optical detection methods that measure intrinsic molecular and cellular optical properties without fluorescent or radioactive...
- The National Institute of General Medical Sciences, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Arizona State University $404,180 on July 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how bacterial predation via the type VI secretion system shapes ecological and evolutionary dynamics in microbial communities. The D'Souza Lab will study T6SS-mediated antagonism in two bacterial...
- The National Institute of General Medical Sciences awarded Arizona State University $300,000 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate synthetic microbial communities and their ecosystem dynamics. The project develops and characterizes synthetic two-component and higher-order E. coli microbial communities with diverse inter-strain interaction topologies, coupling bacterial toxin-antitoxin systems with quorum sensing to create...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Arizona State University $799,995 on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to establish a quantitative framework for understanding reciprocal interactions between biomolecular condensates and cellular growth. The project will use integrated experimental and computational approaches to determine how cellular growth regulates condensate formation, dissolution, and phase-separation...
- Arizona State University was awarded a $309,665 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences on August 15, 2021 to complete work by July 31, 2024. The grant supports the collaborative research project "Toward Lifelike Synthetic Cells via Engineered Control of DNA Replication" under the Biological Sciences program (CFDA 47.074). This program aims to promote progress in the biological sciences and strengthen the nation's scientific...
- The National Institute of General Medical Sciences awarded Arizona State University $378,995 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to decode the toxicity-efficacy paradox in gene and nucleic acid therapies. Over five years through August 31, 2031, the funded research will generate an integrated atlas of escape-induced toxicities using phosphoproteomics, transcriptomics, and mediator profiling to map how endosomal escape location and...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Arizona State University $593,493 on September 1, 2026, to investigate the molecular mechanisms governing microRNA strand selection in Caenorhabditis elegans. The award operates under the Biological Sciences program (CFDA 47.074). The research will establish the first comprehensive mechanistic framework explaining how microRNA strand selection is determined in living organisms, using the roundworm model system...
- The National Institute of General Medical Sciences awarded the University of Florida $386,985 on July 23, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct a five-year investigation into the structure-function relationships of single-stranded DNA (ssDNA) in biological systems. The research will develop methods to probe structured ssDNA in cells, with initial focus on two biomedically relevant lines of investigation. The first examines complex ssDNA...
- The National Institute of General Medical Sciences (NIGMS) awarded the University of Arizona $410,775 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance synthetic bacterial adhesion tools and engineer multicellular bacterial consortia for health-relevant applications. The research focuses on developing novel synthetic cell-cell adhesion features through protein engineering, creating new synthetic genetic circuits that enable controlled...
The National Institute of General Medical Sciences awarded Arizona State University $940,578 on August 6, 2026, to support the continued operation and expansion of DNASU, an academic nonprofit plasmid biorepository, through the Biomedical Research and Research Training program (CFDA 93.859). DNASU maintains a collection of over 585,000 unique plasmids from 1,269 organisms, including complete genome collections and the first complete human plasmid set. The repository acquires plasmids through in-house production via high-throughput cloning and through deposition by outside research groups, then distributes them to academia, industry, and government researchers worldwide via its website at https://dnasu.org/. Over the past three years, DNASU averaged nearly 1,000 orders per year and distributed over 8,701 plasmids to scientists globally, with the website receiving approximately 3,000 unique visitors per month. Users access clone, gene, and vector information; place orders; and link to external resources such as protocols and publications. The award funds database and computer programming, infrastructure upkeep, and collection maintenance and updating—work that the repository's nonprofit sales revenue from clone distribution does not fully support, despite DNASU's progress toward financial sustainability. Prior NIGMS funding through the Protein Structure Initiative added over 93,000 plasmids to the collection and supported software development for clone discovery and use. The period of performance runs from the award date through July 31, 2031. Work is performed in Tempe, Arizona.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $940.6k | 8/6/26 |