This $518,670 federal project grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund the transformation of the early-stage Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase. The key products and services to be delivered include:
Aggregating and integrating newly available 'omics datasets in bone, cartilage, tendon,...
This Project Grant award, with a total funding amount of $412,610.00, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of the research is to better understand how peripheral blood microbiome patterns are associated with knee osteoarthritis (OA). The work aims to determine whether differences in baseline peripheral blood bacterial DNA patterns...
This $350,000 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the therapeutic role of the NFAT1 transcription factor in osteoarthritis (OA) development. The research will be conducted by the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) from August 1, 2024 to July 31, 2029.
Specifically, the research project will (1) evaluate the...
This federal Project Grant award of $456,808 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskelastic and Skin Diseases Research program (CFDA 93.846), will fund the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in bone and cartilage tissue samples. The project aims to advance understanding of disease progression in osteoarthritis and meniscal injury by...
This federal Project Grant award, with ID R24AR084725, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The objective of this $522,334 award, with a period of performance from Sep 19, 2024 to Jul 31, 2028, is to develop a cloud-based biomedical data repository named "BoneBase" that will collect and share bone phenotyping data generated by national...
This $359,207 Project Grant award was made by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The goal of this 4-year research project is to develop optical redox imaging (ORI)-based medical instruments that can diagnose cartilage disease and evaluate therapeutic approaches for osteoarthritis (OA). The award will fund the development of a stress test to diagnose cartilage...
This federal Project Grant award of $410,920 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support research to investigate risk factors for end-stage glenohumeral (shoulder) osteoarthritis. The key objectives are to: 1) determine associations between occupational exposures and osteoarthritis-related shoulder arthroplasty risk, 2) identify genetic variants...
This $348,680 project grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under its Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to develop computational tools for predicting and understanding knee pain spatial patterns in osteoarthritis (OA) patients. The central goal is to build deep learning models to accurately forecast localized, regional, or diffuse knee pain from magnetic resonance imaging (MRI) data, as...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $578,944 to the University of Alabama at Birmingham (UAB) to conduct research on the genetics of osteoarthritis susceptibility, heterogeneity, and progression. The key objectives are to: 1) identify new and fine-map known genetic loci associated with osteoarthritis and joint replacement...
This $1,476,001 Project Grant award from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) aims to determine how adipose (fat) tissue communicates with the knee joint to contribute to the development of osteoarthritis (OA). The research team at the University of California, San Francisco will interrogate three potential mechanisms of direct inter-organ crosstalk: (1) signaling through soluble secreted factors, (2) cell migration or cell-to-cell mediated...
This federal Project Grant award of $533,151 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will support the creation of a biomedical knowledgebase to promote and facilitate the use of the Osteoarthritis Initiative (OAI) data, which contains comprehensive clinical, imaging, and biospecimen data from over 4,796 individuals with or at risk of knee osteoarthritis.
The key products and services to be delivered include:
An online OAI Resource Library providing access to foundational documents, educational materials, analytic tools, and datasets for researchers and instructors.
OAI Engagement Services to directly assist investigators with accessing and leveraging the OAI data, including creating customized data extracts, facilitating collaborations, and providing educational support.
The knowledgebase aims to increase awareness and utilization of the OAI dataset within the broader research community, accelerating discoveries related to osteoarthritis. The award period is from April 1, 2025 to March 31, 2029.