Project Grant R24AI201122

The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $1,999,706 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support the ImmGen Consortium's immunological research through August 31, 2031.

The award funds dissection of gene expression and regulation across all immune system cell lineages through shared data generation pipelines. Specific deliverables include broadening immune transcriptomes analyzed by ImmGen through long-read sequencing to map all splice isoforms and non-canonical transcripts across immune cell differentiation and activation; performing spatial transcriptomics of immune cells across all lymphoid and parenchymal organs at baseline and under various challenges to deliver a systems-level, spatially resolved atlas of immune cell states; and profiling all states of B cells through differentiation and maturation in all tissues during immune and autoimmune responses by combining single-cell RNA-seq, CITE-seq, and BCR analysis. The award also funds charting regulatory networks through high-precision chromatin technologies including fiber-seq, DAF-seq, and deep ATAC-seq to dissect genetic regulatory networks at fiber-level precision and cross-talk of transcription factors across cell types, with generative AI modeling toward understanding genetic regulatory networks across the immune system.

The recipient operates as Harvard Medical School, the research and academic medical enterprise within Harvard University, headquartered in Boston, Massachusetts. Work is performed in Boston, MA. The obligated amount is $1,999,706.