Federal Grant Award Summary

The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, San Francisco $3.5 million under the Allergy and Infectious Diseases Research program (CFDA 93.855) on June 8, 2026, for the Facilitating Accelerated Science and Translation for TB Regimen Development (FAST-TB) initiative. This five-year project, extending through May 31, 2031, will establish community-wide infrastructure and resources to accelerate the evaluation, prioritization, and adoption of new tuberculosis regimens. Led by UCSF's Center for Tuberculosis in partnership with CRDF Global, FAST-TB addresses critical gaps in TB drug development by creating standardized frameworks and tools to streamline the clinical trial and policy implementation process.

The grant will deliver four integrated service tracks: the Knowledge Integration for TB Treatment (KITT) track establishing secure data-sharing frameworks across trial networks and industry partners; the Global Forum for Biomarkers to Accelerate Simpler TB Treatment (GOFAST) track coordinating biomarker evaluation standards; the Population and Cost-Effectiveness (PACE) track generating transmission and cost-effectiveness models; and the Research to Translate and Yield Evidence into Practice (RELAY) track developing implementation strategies and rapid uptake tools. Collectively, these initiatives will produce shared data resources, consensus frameworks, modeling tools, outcome libraries, and implementation templates designed to reduce duplication across studies, improve comparability of findings, and provide standardized evidence to inform regulatory, policy, and implementation decisions.