Project Grant DP2AI184740
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $721,194 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Florida State University (FSU) to conduct research on membrane protein complexes involved in the cell division process of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB). The 5-year project, beginning March 1, 2025, aims to structurally characterize the FtsQ-FtsZ and FtsQ-FtsB-FtsL protein...
- This federal Project Grant award of $819,998.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), to The Regents of the University of California, San Francisco. The purpose of the award is to conduct research to understand how Mycobacterium tuberculosis (M. tuberculosis) infection triggers host cell death mechanisms, with the goal of identifying new therapeutic targets to augment protective...
- This federal Project Grant award, totaling $404,108, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify the key genetic and signaling pathways that enable Mycobacterium tuberculosis (MTB) to form antibiotic persister cells, which can survive prolonged exposure to lethal antibiotics. The research aims to apply genetic and proteomic approaches to...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $750,000 Project Grant to The University of Southern Mississippi to research the role of extracellular polyphosphate in Mycobacterium tuberculosis antibiotic tolerance. The 4-year grant, which begins on Sep 20, 2025 and runs through Aug 31, 2029, aims to investigate the metabolic pathways in M. tuberculosis that regulate extracellular...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,262,539 to Yale University to elucidate the molecular mechanisms underlying the assembly of the mycobacterial cell envelope, a critical barrier to antibiotics. The research aims to investigate the synthesis and transport of mycolic acids, the function of an essential efflux pump, and the regulation of mycomembrane biosynthesis. These studies...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $4,760,584 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program to the Regents of the University of California, San Francisco (UCSF) for the "RAPID RESEARCH FOR DIAGNOSTICS DEVELOPMENT IN TB NETWORK: EPISODE 2 (R2D2 TB NETWORK II)" project. The goal of this project is to address the critical unmet need for better tuberculosis (TB) diagnostics in high-burden...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded a $742,499 Project Grant to the University of Alabama at Birmingham (UAB) for the "Molecular Investigation of Siderophore Secretion and Drug Efflux by Mycobacterium Tuberculosis" research project. This 5-year project, running from August 2025 to July 2030, aims to shed light on the unique siderophore secretion system in Mycobacterium...
- This $811,396 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases under CFDA 93.855 Allergy and Infectious Diseases Research, is focused on understanding the mechanisms of lipid/metabolite and drug transport in Mycobacterium tuberculosis and related mycobacteria. The major objectives are to establish the molecular mechanisms and structures of three specific MMPL transporter proteins and their complexes with interacting partner proteins. Key activities include...
- This $415,978 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) aims to identify novel boron-based inhibitors of mycobacterial class II aminoacyl-tRNA synthetases. The grant supports research at the University of Central Florida, in collaboration with AN2Therapeutics (formerly Anacor Pharmaceuticals), to develop new boron-containing antibiotics effective against Mycobacterium tuberculosis (MTB). The...
This $492,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to conduct biochemical and structural characterization of the elongasome and divisome protein complexes in Mycobacterium tuberculosis (MTB) and the model organism Mycobacterium smegmatis. The research will use bacterial genetics and endogenous protein purifications to understand how these critical protein systems coordinate and interact to support the asymmetric growth and division of mycobacteria, which contributes to antibiotic resistance and disease persistence. The project will be performed by researchers at the University of California, San Francisco (UCSF) over a 5-year period from August 2025 to July 2030. This work aims to provide new insights into mycobacterial cell biology that could inform the development of novel tuberculosis therapeutics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $492.0k | 7/30/25 |