Project Grant R21TR006421
- The National Center for Advancing Translational Sciences at the National Institutes of Health awarded the University of Georgia Research Foundation $830,500 on May 1, 2026, under CFDA 93.350 (National Center for Advancing Translational Sciences) to support drug repurposing research for multiple hereditary exostoses treatment. The project, titled "Repurposing the PI3KA Inhibitor Alpelisib for the Treatment of Multiple Hereditary Exostoses," will evaluate the clinically approved...
- The National Institute of Mental Health awarded Emory University $780,866 on July 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research on human induced pluripotent stem cell (hiPSC) and progenitor heterogeneity as predictors of variability in three-dimensional human neural differentiation. The award funds the Brain Organoid Hub at Emory University to investigate why region-specific brain organoids derived from hiPSCs exhibit high variability in...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts General Hospital a $2.541 million cooperative agreement on May 1, 2026, to develop targeted gene repair therapy for multisystem smooth muscle dysfunction syndrome caused by ACTA2 R179H mutation, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds IND-enabling studies for a novel CRISPR/Cas9-directed adenine base editor delivered via AAV-PR...
- The National Center for Advancing Translational Sciences, National Institutes of Health, awarded the University of Florida $153,500 on August 1, 2026, under CFDA 93.350 (National Center for Advancing Translational Sciences) to conduct pilot studies investigating SCYL2, an understudied protein associated with Arthrogryposis Multiplex Congenita Type 4 (AMC4), a rare developmental disorder. The project tests the hypothesis that SCYL2 participates in clathrin-mediated endocytosis and that...
- SMILE (Sickle Cell Disease Microbiologic and Immunologic Links to Health) - Respiratory Control Research Project Grant Emory University received a $794,661 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), with an award date of September 19, 2025, and a completion date of June 30, 2030. This research initiative investigates how higher-order brain regions interact with brainstem circuits to produce...
- The National Institute of Child Health and Human Development awarded Emory University a $1.517 million cooperative agreement (U54HD122209) on September 15, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865), with performance through August 31, 2030. The award funds ARISEN (Autoimmunity, Rasmussen's, Inflammation & Status Epilepticus Research Network), a multi-center registry and research initiative to investigate rare, sudden-onset immune-mediated...
- The National Heart, Lung, and Blood Institute awarded Emory University $497,998 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 17, 2025, to support research into the molecular mechanisms underlying context-specific RUNX factor functions in directing hematopoietic cell identity. The project addresses how broadly expressed transcription factors regulate distinct gene sets in different developmental programs, focusing on dynamic functions of RUNX transcription factors...
- The National Institute of Child Health and Human Development awarded Emory University $169,310 on March 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research uncovering the role of importin9 in Hedgehog signaling. The research identifies importin9, a member of the karyopherin family, as a novel regulator of Hedgehog pathway signaling. Hedgehog signaling is essential for vertebrate development and adult tissue homeostasis;...
- This Project Grant award from the Defense Health Agency's Military Medical Research and Development program (CFDA 12.420) provides $187,800.00 to Emory University to conduct research on "Enhancing Radiosensitivity in CHD5-Depleted Lung Adenocarcinoma Through Inhibition of Nonhomologous End Joining (NHEJ)." The research project, which has a performance period from Mar 15, 2025 to Mar 14, 2026, aims to investigate innovative medical solutions for transforming healthcare for military...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $547,750 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate human-specific mechanisms governing miR-124 regulation of neuronal development. The research focuses on microRNA biogenesis and function in the human brain, specifically examining how miR-124—the most abundant microRNA in brain tissue—controls spatiotemporal...
The National Center for Advancing Translational Sciences awarded Emory University $860,750 on August 1, 2026, under the NCATS Research Exploration & Refinement (R21) grant program (CFDA 93.350). Emory will develop two complementary, patient-derived experimental systems to interrogate SMAD4-I500V hyperppi and identify small-molecule modulators to normalize TGF-β signaling in Myhre syndrome. The first system is the Myhre iPSC Hyperppi Biosensor System (MIBS), which will use CRISPR-engineering to establish live-cell biosensors in Myhre patient-derived and sibling control induced pluripotent stem cells, enabling allele-specific monitoring of SMAD4-I500V/SMAD3 interactions in their native genomic and cellular context for high-throughput chemical screening and mechanistic dissection. The second is the Cardiac Organoid Phenotyping System (COPS), which will differentiate Myhre and control iPSCs into multicellular 3D cardiac organoids recapitulating cardiomyocyte, fibroblast, and endothelial interplay to define functional disease phenotypes. These platforms address a critical gap in physiologically relevant experimental approaches for studying pathogenic protein-protein interactions in Myhre syndrome, a rare autosomal dominant multisystem disorder. Performance is located in Atlanta, Georgia. The award runs through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/2/26 | ||
| Not listed | $430.4k | 7/28/26 |