Project Grant R00HL173688
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
- This $240,552 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research project titled "Unraveling the Cell Networks in Bone Marrow Through Transcriptomic and Epigenetic Profiling" at the University of Pennsylvania. The project aims to generate a comprehensive single-cell transcriptomic and regulomic map of human bone marrow cells and experimentally establish the mesenchymal cell hierarchy in human bone....
- This federal Project Grant award for $802,301, provided by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research by Weill Medical College of Cornell University to investigate the mechanisms that control the bone marrow "niche" environment and its role in expanding mutated blood stem cells that increase the risk of cardiovascular disease and cancer. The research aims to identify signaling pathways that can be targeted to prevent...
- This Project Grant award of $234,750.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to examine the immunological mechanisms that initiate and orchestrate the development of anti-factor VIII alloantibodies, known as inhibitors, in patients with severe hemophilia A. The research is being conducted by Emory University and seeks to identify key immune pathways and risk factors that predict the likelihood of inhibitor development, with the goal...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the regulation of extramedullary hematopoiesis (EMH) in the liver. The $260,674 award to the Trustees of Columbia University in New York City, New York, with a performance period of January 1, 2025 to August 31, 2025, will fund three specific aims: 1) characterizing the cellular components of the...
- This $445,000 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at The Children's Hospital of Philadelphia (CHOP) to investigate how the tropomyosin 1 gene product impacts the development of hematopoietic stem and progenitor cells and their precursors. The goal is to define genetic determinants of hematopoiesis that could enhance in vitro production of blood cells to support research and development of blood...
- This $153,117 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development of the recipient's independent research career as an academic hematopathology physician-scientist. The key objectives are to study hematopoietic stem and progenitor cell (HSPC) crosstalk and transplantation, with the overarching goal of improving HSPC transplantation outcomes. The award period runs from August 1, 2025 to July 31,...
- This $147,486.00 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of high-fat diet in hematopoiesis (blood cell formation) and clonal hematopoiesis, a condition associated with increased risk of myeloid diseases like myelodysplastic syndrome and acute myeloid leukemia. The award was made to the Regents of the University of Michigan, Ann Arbor for a project period running from Jul 9,...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $216,460 to Albert Einstein College of Medicine to elucidate the interplay between DDX41 and CUX1 mutations in hematopoiesis. The project aims to characterize blood system changes during embryogenesis and adult stages in zebrafish models, as well as leverage human induced pluripotent stem cells, to understand how co-occurring DDX41 and CUX1 mutations cooperate to...
This Project Grant award of $248,999.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Emory University to investigate the molecular mechanisms underlying the context-specific functions of RUNX transcription factors in directing hematopoietic (blood) cell identity. The research aims to determine how RUNX factors dynamically regulate distinct gene programs during early T cell development and megakaryocyte differentiation, as well as leverage a novel cell culture technique to study the roles of transcription factors in the developmental transition from bone marrow progenitors to early thymic progenitors. The award has a performance period from September 17, 2025 to August 31, 2028 and is intended to advance scientific understanding of how broadly expressed transcription factors provide precise functional inputs in different cellular contexts to support healthy blood cell production.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/28/25 |