Project Grant R21TR006236
- Federal Project Grant Award Summary The University of Chicago received a $581,259 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective August 20, 2025, with a completion date of June 30, 2029. This award supports the development of novel methodologies for transcriptomic characterization of membraneless organelles (MLOs)—subcellular structures ranging from 1-200 nanometers to several microns that organize...
- Federal Project Grant Award Summary The University of Chicago received a $451,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 1, 2026, through February 28, 2031. This award supports the development of novel statistical methods to link genetic variants identified through Genome-Wide Association Studies (GWAS) to their underlying regulatory mechanisms and causal genes. The...
- Federal Project Grant Award Summary The University of California, Irvine received a $419,398 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on June 16, 2025, with a completion date of June 15, 2027. This award supports research focused on "Accelerating the Translation of Oligonucleotide Therapeutics by Enhancing Delivery." The project addresses a critical bottleneck in oligonucleotide therapeutic (ONT) development—the...
- Federal Project Grant Award Summary The University of Chicago received a $444,788 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through February 28, 2031. This five-year research project focuses on deciphering piRNA (Piwi-interacting RNA)-based immunity mechanisms in germ cells, with particular emphasis on understanding how germ cells distinguish self from non-self RNA...
- Federal Grant Award Summary The University of Chicago received a $410,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 15, 2026, with a completion date of December 31, 2030. This five-year research initiative develops innovative computational and statistical methods to advance causal inference in genetics and genomics. The project deliverables include novel...
- Federal Grant Award Summary The University of Chicago received a $451,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. This award funds fundamental research investigating how human population demography, genetic structure, and natural selection shape the genetic architecture of human traits. The research will develop novel genomic...
- Federal Project Grant Award Summary The University of Rochester received a $578,733 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with a completion date of February 28, 2031. This five-year research initiative, titled "Elucidating the Biological Roles of tRNA Modification Enzymes," focuses on fundamental biomedical research to advance understanding of how...
- Federal Grant Award Summary Northwestern University received a $440,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded August 1, 2025, with a performance period through July 31, 2027. The grant supports the development of an anti-LTBP4 (Latent TGF-Beta Binding Protein 4) biologic therapeutic to treat Limb Girdle Muscular Dystrophy 2C (LGMD 2C), a rare genetic disorder characterized by progressive muscle weakness with onset typically in...
- Federal Project Grant Award Summary The Broad Institute of MIT and Harvard received a $436,250 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded May 1, 2026, with completion scheduled for April 30, 2028. Under this award, the Broad Institute is developing and validating the RAPID (Rare Disease Analysis Through Pooled Image-Based Identification of Drugs) platform, a novel massively parallel screening technology designed to accelerate drug...
- Federal Project Grant Award Summary The University of Chicago received a $480,083 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 15, 2026 through January 31, 2031. This fundamental research project focuses on understanding how embryonic developmental mechanisms evolve across fly species, with particular emphasis on the natural variation of anterior-posterior axis...
The University of Chicago received a $451,000 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) for a two-year research initiative spanning May 1, 2026, through April 30, 2028. The award supports development of a missense-correcting transfer RNA (tRNA) therapy platform designed to address genetic diseases caused by missense mutations, which represent approximately 30% of human genetic disorders currently lacking effective treatment options. Unlike gene or messenger RNA-based therapies that typically target single mutations, this platform offers the potential therapeutic advantage of treating multiple genetic diseases sharing common missense mutations across different genes. The research project comprises two primary objectives: Aim 1 involves developing a high-throughput engineering platform to screen tens of thousands of potential missense-correcting tRNA candidates simultaneously in cellular models, with emphasis on generating therapeutically viable constructs with reduced cellular toxicity. Aim 2 focuses on identifying missense-correcting tRNA expression variants that maintain therapeutic efficacy while minimizing adverse effects to cells. The initiative centers on tRNAs charged with arginine that read glutamine, histidine, tryptophan, or cysteine codons, corresponding to the most frequent missense mutations in genetic disorders. Upon completion, this research is expected to establish foundational evidence supporting missense-correcting tRNAs as a novel therapeutic modality for rare genetic diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 4/28/26 |