Project Grant R21TR006184
- Federal Grant Award Summary The University of Minnesota received a $226,139 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2025 through June 30, 2027. The primary deliverable is the development and characterization of a human cerebellar organoid model of Spinocerebellar Ataxia Type 1 (SCA1), a dominantly inherited...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota a Project Grant totaling $420,771 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period July 7, 2025 through June 30, 2027. This grant supports research focused on developing next-generation genetic therapies for Artemis-deficient Severe Combined Immunodeficiency (ART-SCID), a primary immune deficiency disorder caused...
- Federal Project Grant Award Summary The University of Florida's Division of Sponsored Research received a $419,375 Project Grant from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350, awarded July 7, 2025, with a completion date of June 30, 2027. This award funds preclinical research and optimization of QTE (Quinone-based Therapeutic Element) therapy for Friedreich's Ataxia (FRDA), a rare inherited neurological disorder characterized by progressive...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $380,000 to the Regents of the University of Minnesota on September 11, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop optimized micellar nanoparticles (MNPs) for delivering digital base editor treatments to address severe combined immunodeficiency A (SCID-A), a primary immunodeficiency disease. The research will utilize a machine...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $395,009 to the University of California, Davis on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year project, extending through July 31, 2027, supports foundational research to develop antisense oligonucleotide (ASO) therapy for ADNP syndrome (Helsmoortel-van der Aa syndrome), a severe...
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $149,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective February 1, 2026, with a completion date of January 31, 2027. The project addresses the molecular mechanisms and therapeutic correction of X-linked myopathy with excessive autophagy (XMEA), a rare autophagic vacuolar myopathy characterized by progressive proximal muscle weakness and...
- Federal Grant Award Summary The University of Minnesota received a $1.31 million Project Grant (DP2 mechanism) awarded September 30, 2025, under the Trans-NIH Research Support program (CFDA 93.310) from the National Institutes of Health (NIH) Office of the Director. This award supports a three-year research initiative (through August 31, 2028) investigating neuroplasticity and cerebral blood flow as key resilience mechanisms in fast-moving superagers—older adults aged 75 and above who maintain...
- The Project Grant award of $404,058 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to identify novel small molecules that stabilize functional, multimeric forms of the TDP43 protein. The goal is to restore TDP43's native RNA binding and splicing regulation functions, which are impaired in frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and other TDP43-related neurodegenerative diseases. The research will leverage high-throughput...
- Federal Grant Award Summary The Regents of the University of Minnesota received a $174,528 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through August 31, 2030. This award supports reverse translational research to identify novel treatment targets for atrial myopathy, a condition involving structural, mechanical, or electrophysiological changes in the atria that may...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the Regents of the University of Minnesota a Project Grant totaling $423,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective July 1, 2025 through June 30, 2027. This exploratory research project delivers scientific investigation into phenylalanine (PHE) biosynthesis as a novel anti-tuberculosis drug target. The primary products include development of...
The University of Minnesota received a $440,019 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective June 1, 2026, through May 31, 2028. The award funds preclinical research evaluating nervonic acid as a preventive therapy for cerebral demyelination in adrenoleukodystrophy (ALD), a rare X-linked neurometabolic disorder characterized by the accumulation of very long-chain fatty acids (VLCFAs) in nerve tissue. The research will conduct placebo-controlled studies in a relevant mouse model to assess the efficacy of nervonic acid in reducing VLCFA accumulation and neuroinflammation in cerebral ALD, with the ultimate goal of establishing proof-of-concept for a safe and effective preventive treatment for this severe neurological condition. This award supports translational science research aligned with NCATS' mission to accelerate the movement of research observations into practical health solutions. Given that cerebral ALD results in mortality within five years without treatment and no approved preventive therapies currently exist for pre-symptomatic patients, the preclinical efficacy data generated through this research will advance understanding of nervonic acid as a potential therapeutic intervention and inform future clinical development pathways for this rare disease population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 5/29/26 |