Project Grant R21TR005519
- Federal Grant Award Summary Yale University received a $1.54M Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for May 31, 2029. The research project, titled "Endothelial Protocadherins in Vascular Development and Disease," will be conducted at Yale's New Haven, Connecticut facility and focuses on understanding the molecular mechanisms by which...
- Federal Grant Award Summary Yale University received a $147,486 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on July 15, 2025, with a completion date of June 30, 2028. The grant supports research to define the role of G3BP1, an RNA binding protein (RBP), in vascular development and blood vessel formation. The research will utilize a novel G3BP1 loss-of-function mutant zebrafish model to...
- Federal Grant Award Summary Yale University received a $706,573 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. The award supports the development of novel statistical methodologies for analyzing multiple and composite outcomes in cluster-randomized trials (CRTs) using win estimands (net benefit, win ratio, win odds). The project will create a suite of...
- Federal Grant Award Summary Yale University received a $2.1 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports fundamental research investigating the biological role and pharmacology of the EXPERA family of membrane proteins, specifically sigma-2 receptor (TMEM97) and transmembrane 6 superfamily member 2 (TM6SF2),...
- Federal Grant Award Summary Yale University received a $610,637 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with completion targeted for March 31, 2031. The grant funds bioengineering research to develop an optimized drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles for locoregional treatment of advanced melanoma. The research will engineer nanoparticles with selective...
- Federal Grant Award Summary Yale University received a $460,740 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through July 31, 2030. The award funds research to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states. The primary deliverables include the application of Proteolysis-Targeting...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Yale University a $191,300 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) on July 4, 2025. This four-year training and research initiative, with a completion date of June 30, 2029, supports the development of Dr. Thomas C. Binns, MD, as an independent investigator specializing in nanoparticle-phagocyte...
- Federal Grant Award Summary Yale University received a $304,970 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026 through May 31, 2031. This award funds the development of next-generation mass spectrometry (MS)-based technologies designed to directly analyze membrane protein complexes and their lipid environments with precise molecular and nanoscale spatial resolution....
- Federal Project Grant Award Summary Yale University received a $2.014 million Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective June 1, 2026, with completion targeted for May 31, 2030. The award funds development of a synthetic biology tool designed to engineer proteins with multiple posttranslational modifications (PTMs) and elucidate their binding functions. The project leverages Genomically...
- Federal Project Grant Award Summary Yale University received a $2.31 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 8, 2025, with a completion date of September 7, 2029. This four-year research initiative will investigate the molecular mechanisms governing large dense-core vesicle (LDCV) fusion with the plasma membrane, a process critical to secretion of peptides,...
Yale University received a $455,604 Project Grant from the National Center for Advancing Translational Sciences (NCATS), Federal Grant Program (CFDA 93.350), awarded on May 1, 2026, with a completion date of April 30, 2028. The grant funds development of a novel HDL-mediated RNA delivery platform (C15-900 lipid nanoparticle) designed to deliver targeted anti-endothelial-to-mesenchymal transition (anti-EndMT) therapy for cardiovascular diseases. The platform employs innovative ionizable lipid design to achieve unprecedented endothelial cell-specific delivery, addressing the therapeutic challenge of vascular disease driven by endothelial dysfunction while minimizing off-target effects associated with systemic transforming growth factor-beta (TGFβ) inhibition. The project deliverables encompass two complementary research objectives. Aim 1 focuses on establishing critical quality attributes and manufacturing parameters through systematic formulation evaluation, comprehensive particle characterization (size, polydispersity index, zeta potential), biodistribution studies using endothelial lineage-traced mice, and advanced imaging and flow cytometry validation across multiple vascular beds. Aim 2 demonstrates therapeutic efficacy using a hypoxia-induced pulmonary hypertension model to evaluate the platform's ability to modulate TGFβ pathway signaling, assess hemodynamic and histological outcomes, and establish translational parameters for clinical development. This systematic approach establishes standardized manufacturing and quality control processes to advance the platform technology toward clinical translation as a targeted RNA therapeutic.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $455.6k | 4/28/26 |