Project Grant R21TR005230
- Federal Project Grant Award Summary Oregon Health & Science University received a $1,992,234 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective July 1, 2025, through April 30, 2030. This award funds research on allogeneic hepatocyte transplantation designed to overcome critical barriers to therapeutic liver cell therapy by developing genetically...
- Federal Project Grant Award Summary Oregon Health & Science University received a $1.42 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through June 30, 2030. The award supports basic biomedical research characterizing cellular heterogeneity and defining cell states in specific kidney tubule segments—the thick...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) was awarded $390,000 in Project Grant funding from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the five-year period from September 1, 2025, through August 31, 2030. The grant supports the development of advanced analytical methods for high-throughput characterization of extracellular RNA (cfRNA), cell-free DNA (cfDNA), and...
- Federal Project Grant Summary: Intraductal Gene Therapy for Liver Cirrhosis Oregon Health & Science University (OHSU) received a $686,129 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded January 16, 2026, with a completion date of November 30, 2029. The research systematically explores the intraductal route of administration for gene therapy...
- Federal Grant Award Summary Oregon Health & Science University received a $662,913 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through July 31, 2029. The research focuses on developing a peptide amphiphile (PA)-based universal drug delivery platform designed to address significant limitations of...
- Federal Grant Award Summary Oregon Health & Science University received a $780,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 15, 2025, through May 31, 2027. The award funds research investigating allelic expression imbalance in trisomy 21 (Down syndrome), with particular emphasis on understanding epigenetic mechanisms that regulate dosage-sensitive genes on chromosome 21. The research examines how epigenetic...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $164,745 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective April 1, 2026 through March 31, 2031. The award funds research to investigate the mechanisms of maternal renal and gestational dysfunction following recovered acute kidney injury (AKI). The research...
- Federal Grant Award Summary Oregon Health & Science University received a $429,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period April 1, 2026 through March 31, 2028. This award supports novel genetic research to elucidate critical signaling pathways in Leishmania donovani, a parasitic pathogen responsible for visceral leishmaniasis, a neglected tropical disease...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
- Federal Grant Award Summary The Ohio State University received a $374,199 Project Grant from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) awarded on July 7, 2025, with completion anticipated by June 30, 2027. The grant supports development of an in situ capsid protein and deoxyribonucleic acid (DNA) imaging platform designed to characterize and quantify therapeutic adeno-associated virus (AAV) titers with enhanced precision and accuracy. The research addresses...
Oregon Health & Science University (OHSU) received a $448,013 Project Grant award from the National Center for Advancing Translational Sciences (NCATS, CFDA 93.350) effective May 1, 2026, with completion targeted for April 30, 2028. The grant funds research exploring adeno-associated virus (AAV) vector-mediated gene therapy for Alport Syndrome using a canine disease model. This project addresses a significant translational science bottleneck by investigating innovative therapeutic approaches for a rare genetic kidney disease that affects approximately 1 in 2,000 to 5,000 people and currently lacks curative treatment options beyond partial disease management with angiotensin-converting enzyme inhibitors. The core deliverable involves preclinical proof-of-concept research to advance gene therapy technology toward clinical application for Alport Syndrome, which manifests as progressive chronic kidney disease, hearing loss, and ocular impairment resulting from deficiency in Type IV collagen chains. The research will leverage OHSU's extensive translational science capabilities and animal model expertise to overcome critical challenges in kidney-targeted gene delivery and address the packaging capacity limitations of AAV vectors for large therapeutic genes. This award aligns with NCATS' mission to accelerate the translation of scientific discoveries into practical health solutions by supporting high-impact research that removes bottlenecks in the drug development pipeline for rare genetic diseases.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.0k | 4/21/26 |