Project Grant R21OD042617
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $153,560 to the University of California, Santa Barbara on November 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). The recipient will conduct physiological, molecular, and bioinformatic experiments to determine the role of circadian rhythms in modulating wound healing and whole-body regeneration, with focus on identifying the...
- The National Institute of General Medical Sciences awarded $1.386 million to the University of Arizona on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to identify and modulate mechanistic cellular pathways of quiescence deepening and transition to senescence. The research focuses on elucidating the transcriptomic and epigenetic mechanisms controlling quiescence depth—a cellular dormancy state—and its progression into senescence by modulating the...
- The National Institute of General Medical Sciences awarded Albert Einstein College of Medicine $420,000 on September 1, 2026, to investigate the molecular mechanisms controlling a diapause-like dormant cell state under CFDA 93.859 (Biomedical Research and Research Training), assistance type Project Grant R35GM163637. The research characterizes how somatic cells adopt a reversible, quiescence state resembling embryonic diapause in response to cellular stress and damage. Work addresses three...
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $1,601,981 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate protein aggregation mechanisms in hematopoietic stem cells and their relationship to stem cell aging. The research examines how hematopoietic stem cells traffic misfolded proteins to aggresomes—cytosolic inclusion bodies that are substrates for selective autophagy—and tests the hypothesis...
- The National Institute of General Medical Sciences awarded the University of Virginia $395,698 on February 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how the structural complexity of stem cell niches enables stem cell function during development and homeostasis. The research examines how niche structure and spatial organization coordinate the timing, intensity, and duration of signaling that controls stem cell activity. The work uses the C....
- The National Institute of General Medical Sciences awarded Cornell University $415,686 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study cellular and molecular mechanisms governing stem cell resilience. The research uses freshwater planarians as a model organism to identify conserved mechanisms by which stem cells resist deterioration and overcome genotoxic stress. Over the five-year performance period ending April 30, 2031, the work pursues...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Boston $425,333 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular and molecular mechanisms of stem and progenitor cell development during tissue homeostasis and after injury. The research uses the Drosophila melanogaster blood system as a model to examine how multiple cell types within stem and progenitor cell niches use inflammatory...
- The National Cancer Institute awarded Icahn School of Medicine at Mount Sinai $712,912 for research into the functional determinants of disseminated tumor cell dormancy in the brain under the Cancer Biology Research program (CFDA 93.396), effective August 1, 2026. The recipient will conduct a five-year project through July 31, 2031 to explore how breast cancer cells reshape the brain microenvironment to establish and maintain a dormancy-supportive niche. The research centers on the role of...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded New York University $421,737 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop data-driven, predictive biophysical models of molecular mechanisms underlying cellular quiescence in microorganisms. The research focuses on quantitative relations between physiological traits and molecular processes in...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of California, Santa Barbara $430,375 on August 1, 2026, under the Research Infrastructure Programs (CFDA 93.351) to fund basic research on reversible stem cell dormancy in the basal chordate Botrylloides diegensis. The award supports investigation of mechanisms controlling stem cell dormancy and re-activation, using B. diegensis as a model organism. This species undergoes stress-induced whole-body resorption, leaving a vascular mat containing pluripotent stem cells and a supporting niche that can survive months under dormant conditions (heat, cold, starvation, or hypoxia). Upon return to normal environment, pluripotent stem cells rapidly re-activate to regenerate the entire body. The research addresses fundamental gaps in understanding how extrinsic signals from surrounding cells and the extracellular matrix instruct dormancy entry and exit—knowledge with implications for tissue regeneration, disease progression, and aging. The findings may inform strategies for controlling metastatic cancer stem cells, which transition to dormancy after migration to distant tissues and can reactivate years or decades later, contributing to the 90 percent of cancer deaths attributable to metastases. Performance occurs in Santa Barbara, California, from August 1, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $430.4k | 7/28/26 |