This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research, aims to evaluate the effect of exogenous anti-Müllerian hormone (AMH) on ovarian function and fertility in non-human primates. The $724,714 award will support research to test hypotheses that AMH can induce contraception without disrupting estradiol homeostasis, reduce ovarian aging, and potentially...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $800,485 to Oregon Health & Science University (OHSU) to investigate the role of human-specific 3D genome conformation in brain development and disease. The key research objectives are to: 1) analyze Hi-C data from cortical neural progenitor cells and neurons derived from human, chimpanzee, orangutan, and rhesus macaque to identify human-specific...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) is providing $194,375 to the University of Wisconsin - Madison to develop advanced genome editing tools for the zebrafish model organism. The key products to be delivered include: Establishing a reliable method for generating conditional knockout alleles in zebrafish using a synthetic exon-mediated integration approach to insert LoxP sites. This will enable conditional...
The National Institute of Child Health and Human Development (NICHD) awarded a $704,154 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Oregon Health & Science University (OHSU). The purpose of this 5-year study is to investigate how maternal diet-induced metabolic dysfunction impacts epigenetic programming and developmental processes in rhesus macaque embryos and fetuses. Specifically, the researchers will assess alterations in DNA...
This Project Grant award, provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to rapidly develop advanced mouse resource strains through the application of Prime Editing technology. The $265,500 award, granted on September 1, 2024, will fund research at the Jackson Laboratory to create a novel combinatorial system that can efficiently modify thousands of mouse genes by applying Prime Editing techniques. The key innovation is the...
The National Institute of General Medical Sciences (NIGMS) awarded a $307,257 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Sxrna Technologies, Inc. to develop a rapid cloning technology called SXRNA-SELECT. This technology aims to decrease the time required to clone mammalian cells and increase protein yields for biotherapeutic production. The key objectives are to optimize the delivery protocol for plasmids and SXRNA-bait, demonstrate selection...
The National Institutes of Health (NIH) awarded Emory University a $8,000,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to expand the specific-pathogen-free (SPF) rhesus macaque breeding colony at the Emory National Primate Research Center. The new animal housing will consist of 16 indoor/outdoor run areas and support space to facilitate targeted genetic breeding for SIV/AIDS research. This expansion is intended to provide additional animals to support the $23.8M...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research, supports the development of high-throughput methodologies to rapidly measure and optimize in vivo adeno-associated virus (AAV)-mediated homology directed repair (HDR) gene editing efficiency in mice. The $425,348 award to Indiana University Indianapolis, a research-intensive state university, aims to create novel...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $746,895 to the Regents of the University of Minnesota to establish a non-human primate platform in genetically modified pigs. The goal is to engineer a humanized heart in a gene-edited pig that could serve as an alternative organ source for cardiac transplantation. The key products and services to be delivered...
The National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) awarded a $775,888 Project Grant (CFDA 93.351) to the La Jolla Institute for Immunology (LJI) to create and validate a modular CRISPR-ready HLA transgenic mouse platform. The project aims to produce a CAS9-expressing platform mouse strain with humanized B2M, CD8, CD4, and absence of mouse MHC II, which will enable researchers to easily generate HLA class I and II transgenic mouse models for studying a broad...