Project Grant R21NS152782
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $460,625 on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate time-dependent membrane proteomics in circadian pacemaker neurons. The recipient will use cutting-edge proteomic approaches combined with biotin proximity labeling to survey the membrane proteome of circadian neurons during the...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of the University of Pennsylvania $128,115 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, award K99NS149278). The award funds investigation into the mechanisms by which irregular light exposure impairs memory across generations via epigenetic changes affecting neural circuits, germline-to-brain signaling, and neurotransmitters. Using...
- The National Institute of Neurological Disorders and Stroke awarded California Institute of Technology $408,947 on September 1, 2026, under Assistance Listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) to investigate the neural mechanisms underlying temporal integration in the fruit fly Drosophila, with research performed in Pasadena, California through August 31, 2031. The project uses the haltere-motor sensory system in fruit flies—which detects...
- The National Institute of Neurological Disorders and Stroke awarded Cold Spring Harbor Laboratory $200,900 on May 6, 2026, to deliver a three-week intensive training course titled "Drosophila Neurobiology: Genes, Circuits & Behavior" under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The course introduces students at all career levels—from advanced graduate students to principal investigators—to state-of-the-art...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of The University of Pennsylvania $100,228 on December 1, 2026, to investigate a sleep-promoting circuit across the lifespan in Drosophila melanogaster under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The project characterizes how sleep-regulating neural circuits function in fruit fly larvae and whether those circuits persist and maintain their...
- The National Institute of General Medical Sciences awarded the University of Cincinnati $760,178 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms that determine circadian rhythm period and light-dependent phase shift. The recipient will combine mathematical modeling, statistical uncertainty quantification methods, and experimental validation to elucidate how transcriptional and translational feedback loops...
- The National Institute of Neurological Disorders and Stroke awarded The Ohio State University $630,925 on May 1, 2026, to investigate circadian clock physiology in cortico-limbic brain circuits and its role in regulating complex behavioral states including mood, memory, and executive function. The research examines how transcriptional timing feedback loops and clock oscillators outside the suprachiasmatic nucleus operate at cellular and systems levels within cortico-limbic circuits, and how...
- The National Institute of Neurological Disorders and Stroke awarded Texas A&M University $500,307 on April 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cross-neuronal structural plasticity in Drosophila motor circuits. The research addresses how different neuron and synapse types undergo structural rewiring in response to neural injury, with focus on how premotor neurons, motor neurons, and muscles in...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Davis $129,261 on July 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the molecular mechanisms underlying sleep disruption in Smith-Kingsmore Syndrome. The research develops Drosophila melanogaster animal models of Smith-Kingsmore Syndrome (SKS), a genetic disorder caused by gain-of-function mutations in the...
- The National Institute of General Medical Sciences awarded California Institute of Technology $1.872 million on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on mechanisms in the mammalian circadian clock. The research addresses gaps in understanding the central transcription-translation feedback loop (TTFL) that drives circadian oscillations, which regulate sleep-wake patterns, metabolism, and immune responses. The work comprises...
The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $433,125 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate genes and neurons associated with circadian chronotype across Drosophila species. The project quantifies locomotor activity patterns across 63 related Drosophilid species to identify genetic and neural correlates of morning and evening chronotypes. Work focuses on two primary aims: conducting unbiased comparative genomic analyses using available reference genome assemblies to identify novel chronotype-associated genes, and evaluating chronotype-associated variation between species in regulatory elements and expression of known circadian genes. The research builds on decades of circadian research in Drosophila melanogaster, which displays limited chronotype variation within wildtype populations. By examining multiple species across the Drosophilidae family, the project exploits substantial phenotypic variation—ranging from strongly morning-biased to strongly evening-biased patterns—to overcome constraints that prevent identification of genetic determinants of chronotype in single-species models. Performance occurs in Los Angeles, California. The award period runs from September 2, 2026, through August 31, 2028. This is a Project Grant, classified as assistance funding rather than procurement.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 9/2/26 |